Biophysical and Physiological Effects of Solar Radiation on Human Skin (eBook)

Paolo U. Giacomoni received a Laurea in Atomic Physics from the University of Milano and a Ph. D. in Biochemistry from the University of Paris. He was a teacher at the University of Paris, and was a fellow scientist at University of California, San Diego, at the University of Wisconsin, Madison and at the Deutsches Krebsforschungszentrum in Heidelberg. He is Executive Director-R&D, at Clinique Laboratories, Inc. in Melville, N.Y He discovered that UV radiation elicits heat shock response and impairs energy metabolism in the epidermis. He worked on the pro-oxidative behavior of UVA radiation and discovered that DNA damage by UVA requires Oxygen and transition metals. As consequence, he proposed the now widely accepted micro-inflammatory model of skin aging and his laboratory was one of the twelve laboratories, which created the European Union-sponsored Network on Molecular Gerontology. He was among the founders of the European Society for Photobiology and was elected Secretary of the Society for two successive two-year terms.

Preface; Part I Physiological effects; Chapter 1: Damages from acute vs chronic solar exposure; Chapter 2: Inflammation after solar radiation; Chapter 3: Pigmentation after solar radiation; Chapter 4: Skin color, melanin, race/ethnicity and UV-induced DNA damage; Chapter 5: The effects of solar radiation on the immune response in humans; Chapter 6: Genetic background and UVR-induced skin cancer; Chapter 7: Aging after UV-irradiation: dermis; Chapter 8: The effects of visible and near infrared light in humans; Part II Biochemical mechanisms; Chapter 9: UV-induced DNA damage; Chapter 10: Lipid and protein damage provoked by UV radiation: mechanisms of indirect photo-oxidative damage; Chapter 11: UVA and inducible protection; Chapter 12: Damaged proteins: repair or removal; Chapter 13: DNA repair therapy; Index