Applied Biophysics for Drug Discovery (eBook)

Donald Huddler, Widener University Delaware Law School, Wilmington, USA. Edward R. Zartler is Chief Scientific Officer at Quantum Tessera Consulting, LLC, USA.

List of Contributors

1. Introduction
Donald Huddler

2. Thermodynamics in Drug Discovery
OBrienMarkova&Holdgate

3. Tailoring Hit Identification and Qualification Methods for Targeting Protein-Protein Interactions
Björn Walse, Andrew P. Turnbull, Susan M. Boyd

4. HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY IN DRUG DISCOVERY
Thorleif Lavold, Roman Zubarev and Juan Astorga-Wells

5. MICROSCALE THERMOPHORESIS IN DRUG DISCOVERY
Tanja Bartoschik, Melanie Maschberger, Alessandra Feoli, Timon André, Philipp Baaske, Stefan Duhr and Dennis Breitsprecher

6. SPR Screening - Applying the new generation of SPR hardware
Kartik Narayan and Steve Carroll

7. Weak Affinity Chromatography (WAC)
Sten Ohlson* and Minh-Dao Duong-Thi

8. 1D NMR Methods for Hit Identification
Mary J Harner, Guille Metzler, Caroline A Fanslau, Luciano Mueller, William J Metzler

9. Protein-Based NMR Methods Applied to Drug Discovery
Alessio Bortoluzzi, Alessio Ciulli

10. Applications of Ligand and Protein-observed NMR in Discovery
Isabelle Krimm

Conclusion

11. Using Biophysical Methods to Optimize Compound Residence Time
G. A. Holdgate, P. Rawlins, M. Bista, C. J. Stubbs

12. Applying biophysical and biochemical methods to the discovery of allosteric modulators of the AAA ATPase p97
Stacie L. Bulfer and Michelle R. Arkin

13. Driving Drug Discovery with Biophysical Information - Application to Staphylococcus aureus Dihydrofolate Reductase (DHFR)
Parag Sahasrabudhe, Veerabahu Shanmugasundaram, Mark Flanagan, Kris A. Borzilleri, Holly Heaslet, Anil Rane, Alex McColl, Tim Subashi, George Karam, Ron Sarver, Melissa Harris, Boris A. Chrunyk, Chakrapani Subramanyam, Thomas V. Magee, Kelly Fahnoe, Brian Lacey, Henry Putz, J. Richard Miller, Jaehyun Cho, Arthur Palmer III and Jane M. Withka

14. Assembly of fragment screening libraries: Property and diversity analysis
Bradley C. Doak, Craig J. Morton, Jamie S. Simpson & Martin J. Scanlon

Index