Mysteries in Muscle Contraction

Haruo Sugi was appointed instructor in the Department of Physiology of the University of Tokyo, Japan, in 1962 and worked at Columbia University and the National Institutes of Health, USA, from 1965 to 1967. He was a professor in and chair of the Department of Physiology, Teikyo University Medical School, Japan, from 1973 to 2004, when he became emeritus professor. Prof. Sugi organized international symposia on muscle contraction six times from 1978 to 2004 and has edited three books. From 1995 to 2005, he was chair of the Muscle Commission in the International Union of Physiological Sciences.

Historical Background. Dogmas of Huxley–Simmons Model Not Supported Experimentally. New Methods and New Dogmas and Their Shortcomings. The Swinging Lever Arm Hypothesis: A Prominent Current Dogma. Electron Microscopic Recording of ATP-Induced Myosin Head Movement. Evidence against Current Dogmas of Muscle Contraction as Revealed by the Effect of Antibodies to Myosin Head. Electron Microscopic Recording of Myosin Head Power Stroke: Possible Sequence of Actin–Myosin Interaction in Muscle. The Fenn Effect: A fundamental Mystery in Muscle. Load-Dependent Mechanical Efficiency of Myosin Heads. Past History-Dependence of Myosin Head Performance. Mysteries in Unfamiliar Muscle and Motile Systems.