Silica-coated Magnetic Nanoparticles (eBook)

1. Prof. Dr. Verónica Lassalle graduated as Bachelor in Chemistry on 2000 at the National University of South (UNS, Argentina). She obtained her PhD degree in Chemistry from Pilot Plant of Chemical Engineering (PLAPIQUI, Argentina) on 2006 in the topic “Chemical modification of SBS copolymers”. Currently, she is Senior Researcher (CONICET) and full Professor at the Chemistry Institute of South (INQUISUR), Bahía Blanca, Argentina. She participates of one Cooperation Project with Biotechnological and Genetic Engineering Centre (CIGB) from La Habana, Cuba, in the topic “Development and Research on biodrugs with antitumoral activity. A study on the delivery systems and intracellular signalization” granted by MinCyT (Argentina) and CITMA (Cuba).   2. Prof. Dr. Mariela A. Agotegaray was born in October 1982 in Bahia Blanca, Argentina. She obtained a degree in Biochemistry at the National University of the South, Bahia Blanca and at the same University she defended her doctoral thesis entitled "Coordination Complexes of Copper (II) with Fenoprofen. Chemical, Therapeutics and Toxicology”. She has developed postdoctoral studies at INQUISUR (Institute of Chemistry South), National University of the South, on "Synthesis of magnetic nanoparticles with applications in transportation and controlled release of non-steroidal anti-inflammatory drugs". She currently is Scientific Researcher for CONICET (National Council of Scientific and Technical Research) at INQUISUR, working on "Design of nanoparticles with magnetic properties and their application in the treatment of inflammatory and cardiovascular diseases”.

1. Introduction1.1. Magnetic nanoparticles for biomedical applications: special emphasis as targeted drug systems.1.2. Solid silica as platform for drug loading and transport2. Chemical overview2.1. Synthesis of solid silica-coated magnetic nanoparticles for drug targeting2.2. Drug loading and release for specific diseases2.3. Characterization techniques and drug quantification3. Biological features    3.1. Pharmacokinetics and biodistribution of magnetic silica nanoparticles    3.2. Metabolism and elimination of magnetic component and silica coating4. Toxicological insights     4.1. Biocompatibility of solid silica-coated magnetic nanoparticles: an overview on specific components and on magnetic systems.     4.2. In vitro and in vivo toxicology studies.5. Overview on applications for the treatment of specific diseases6. New insights on silica-coated magnetic nanoparticles: improving the performance of drug loading and release.