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High Throughput Screening in Drug Discovery
Productivity Press (Verlag)
978-1-4987-0802-9 (ISBN)
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Quick preclinical drug development guide. Assay technologies in drug screening. HIGH THROUGHPUT SCREENING. Design and implementation of high throughput screening assays. Creation of a small high-throughput screening facility. Informatics in compound library management. Statistics and decision making in high throughput screening. Enzyme assay design for high throughput screening. Enabling the large scale analysis of quantitative high throughput screening data. Compound management for drug screening. HTS from natural extracts, fractionation to identification. HTS from chemical libraries, SAR, HtoL optimization. Emerging novel HTS technologies for cell-based assays. Application of fluorescence polarization in HTS assays. Cell-based assays for high-throughput screening. HIGH CONTENT SCREENING. High content screening platforms. High content screening assay development. HCS data analysis. High throughput automated confocal microscopy. High throughput automated FACs. Fluorescent proteins and engineered cell lines. Reporter gene assay. Exploiting network biology for drug discovery. OTHER SYSTEMS. In yeasts. In C elegans. In zebrafish, droshophila. NMR. Virtual screening. APPLICATIONS. Screening G-protein coupled receptors: Measurement of intracellular calcium using the fluorometric imaging plate reader. In vitro strategies for ion channel screening in drug discovery. High throughput screening of the cyclic AMP-dependent protein kinase (PKA) using the caliper microfluidic platform. Protein kinases and phosphatases. Nuclear hormone receptor screens. Protein/protein interaction–virtual. FRET.
Erscheint lt. Verlag | 15.2.2019 |
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Reihe/Serie | Drugs and the Pharmaceutical Sciences |
Verlagsort | Portland |
Sprache | englisch |
Maße | 178 x 254 mm |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pflege | |
Medizin / Pharmazie ► Pharmazie ► PTA / PKA | |
Technik | |
ISBN-10 | 1-4987-0802-1 / 1498708021 |
ISBN-13 | 978-1-4987-0802-9 / 9781498708029 |
Zustand | Neuware |
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