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Tissue and Organ Regeneration in Adults

Extension of the Paradigm to Several Organs

Ioannis V. Yannas (Autor)

Buch | Softcover

332 Seiten

2016 | Softcover reprint of the original 2nd ed. 2015
Springer-Verlag New York Inc.
978-1-4939-5027-0 (ISBN)

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This textbook describes the basic principles of induced organ regeneration in skin and peripheral nerves and extends the original successful paradigm to other organs. A set of trans-organ rules is established and its use in regeneration of several organs is illustrated from the works of several independent investigators who worked with a variety of organs, such as the lung, the bladder, and the Achilles tendon, using collagen-based scaffolds somewhat similar to the original one. These critical medical treatments fill the clinical need that is not met by organ transplantation.

New to this second edition:

New information extending the paradigm of tissue regeneration from organ regeneration in skin and peripheral nerves to other organs

Guidelines, known as trans-organ rules, are described for the first time for extending this unique medical treatment to organs of several medical specialties

The work serves as a comprehensive text and reference for students and practitioners of tissue engineering

Dr. Ioannis V. Yannas is a professor of Mechanical and Biological Engineering at MIT.

The Irreversibility of Organ Injury.- Nonregenerative Tissues.- Experimental Methods I. The Anatomically Well-Defined Wound.- Experimental Methods II. The Defect Closure Rule.- Regeneration of Skin.- Regeneration of a Peripheral Nerve.- Minimum Reactants Required for Synthesis of Skin and Peripheral Nerves; Extension to Tissues of Other Organs.- An Antagonistic Relation Between Wound Contraction and Regeneration.- Molecular biology of contraction blockade by active scaffolds.- The Scaffold Regeneration Paradigm and its Consequences.

Erscheinungsdatum	02.10.2016
Zusatzinfo	21 Illustrations, color; 40 Illustrations, black and white; XXIII, 332 p. 61 illus., 21 illus. in color.
Verlagsort	New York
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Dermatologie
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Technik ► Maschinenbau
	Technik ► Medizintechnik
	Technik ► Umwelttechnik / Biotechnologie
Schlagworte	Alpha1beta1 integrin • Alpha2beta1 integrin • Assay for dermis • Assay for scar • Axon elongation • Bladder Regeneration • Blocking scar formation • Collagen-binding integrins • Collagen fiber orientation • Collagen scaffold regeneration paradigm • Contractile cell capsule • Contractile cells • Contraction blockade • Critical axon elongation • Integrin ligands • Ligand density of scaffold surface • liver regeneration • Mechanism of Induced Regeneration • Mechanism of scar formation • Molecular biology of scaffold activity • Myofibroblast orientation • Myofibroblasts • Neuroma • Neuroma blocking • peripheral nerve regeneration • Regeneration of Organs • Regeneration paradigm • Scaffold regeneration paradigm • Scar formation • Skin regeneration • Surface chemistry of scaffolds • Tendon Regeneration • Tissue engineering • Wound contraction • Wound Healing Mechanism
ISBN-10	1-4939-5027-4 / 1493950274
ISBN-13	978-1-4939-5027-0 / 9781493950270
Zustand	Neuware