ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins (eBook)

Honghui Zhou is a Senior Director and Janssen Fellow, at Janssen Research & Development, LLC and US head of Pharmacological and Translational Modeling. Board-certified by the American Board of Clinical Pharmacology and a Fellow of American Association of Pharmaceutical Scientists (AAPS) and American College of Clinical Pharmacology (ACCP), he has authored 200 peer-reviewed scientific papers, book chapters, and conference abstracts and co-edited the book Drug-Drug Interactions for Therapeutic Biologics (Wiley, 2013). Frank-Peter Theil heads nonclinical development at UCB Biopharma. Dr. Theil has authored and co-authored 40 research publications, three book chapters and he has given numerous invited presentations at national and international scientific meetings. He is a member of the American Association of Pharmaceutical Scientists (AAPS) and American Society of Clinical Pharmacology and Therapeutics (ASCPT).

"At the outset, one?s impressed with the scope of the book; it provides an outline of very diverse topics starting with the basics of protein engineering and how these are used to design and manipulate the ADME properties of recombinant and synthetic proteins...The authors have to be congratulated on their endeavor to stitch these topics together in a single book...With such a wide range of topics, even an experienced scientific practitioner in this area is likely to find something new to engage them and expand their knowledge...In summary, an excellent and comprehensive book for beginners to the CP/PK area to acquaint themselves with the area of biologics (specifically mAb) CP/PKPD principles and for experienced CP/PK scientists for reference." (CPT: Pharmacometrics & Systems Pharmacology, March 2017)