Arsenic (eBook)

Exposure Sources, Health Risks, and Mechanisms of Toxicity
eBook Download: PDF
2015
John Wiley & Sons (Verlag)
978-1-118-87659-6 (ISBN)

Lese- und Medienproben

Arsenic - J. Christopher States
Systemvoraussetzungen
171,99 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen
This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.

* Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world
* Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models
* Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity
* Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists
* Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure

J. Christopher States, PhD, is Professor, University Scholar and Vice Chair for Graduate Education in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles.

Contributors ix

Preface xiii

Part I Fundamentals of Arsenic Exposure and Metabolism 1

1 History of Arsenic as a Poison and a Medicinal Agent 3
Michael F. Hughes

2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23
David A. Polya and Michael Lawson

3 Remediation of Arsenic in Drinking Water 61
Cathleen J. Webb and Arden D. Davis

4 The Chemistry and Metabolism of Arsenic 81
David J. Thomas

Part II Epidemiology and Disease Manifestations of Arsenic Exposure 111

5 Human Population Studies and Nutritional Intervention 113
Yu Chen and Fen Wu

6 Skin Manifestations of Chronic Arsenicosis 127
Nilendu Sarma

7 Lung Cancer and Other Pulmonary Diseases 137
Cara L. Sherwood and R. Clark Lantz

8 Bladder Cancer and Arsenic 163
Matthew K. Medeiros and A. Jay Gandolfi

9 Neurological Effects of Arsenic Exposure 193
Dominic B. Fee

10 Diabetes Mellitus 221
Miroslav Styblo and Christelle Douillet

11 Hepatotoxicity 249
Gavin E. Arteel

12 Genetic Epidemiology of Susceptibility to Arsenic-Induced Diseases 267
Mayukh Banerjee and Ashok K. Giri

Part III Mechanisms of Toxicity 289

13 Arsenic Interaction with Zinc Finger Motifs 291
Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu

14 Role in Chemotherapy 315
Koren K. Mann and Maryse Lemaire

15 Genotoxicity 347
Ana Maria Salazar and Patricia Ostrosky-Wegman

16 Arsenic and Signal Transduction 369
Ingrid L. Druwe and Richard R. Vaillancourt

17 Stem Cell Targeting and Alteration by Arsenic 397
Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes

18 Epigenetics and Arsenic Toxicity 421
Somnath Paul and Pritha Bhattacharjee

Part IV Models for Arsenic Toxicology and Risk Assessment 439

19 Cancer Induced by Exposure to Arsenicals in Animals 441
Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes

20 Arsenic-Induced Cardiovascular Disease 453
Aaron Barchowsky and J. Christopher States

21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469
Iain L. Cartwright

22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495
Elaina M. Kenyon and Harvey J. Clewell, III

23 Considerations for a Biologically Based Risk Assessment for Arsenic 511
Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager

24 Translating Experimental Data to Human Populations 535
J. Christopher States

Index 549

Erscheint lt. Verlag 1.10.2015
Sprache englisch
Themenwelt Studium 2. Studienabschnitt (Klinik) Pharmakologie / Toxikologie
Studium Querschnittsbereiche Prävention / Gesundheitsförderung
Naturwissenschaften Chemie Anorganische Chemie
Technik
Schlagworte Arbeitssicherheit u. Umweltschutz i. d. Chemie • Arsenic, arsenic exposure, arsenic health risks, mechanisms of toxicity, arsenic metabolism, epidemiology and disease, arsenic toxicology, animal models, arsenic risk assessment • Chemical and Environmental Health and Safety • Chemie • Chemistry • Environmental Toxicology • Epidemiologie u. Biostatistik • Epidemiology & Biostatistics • Gesundheits- u. Sozialwesen • Health & Social Care • Umwelttoxikologie
ISBN-10 1-118-87659-8 / 1118876598
ISBN-13 978-1-118-87659-6 / 9781118876596
Haben Sie eine Frage zum Produkt?
PDFPDF (Ohne DRM)

Digital Rights Management: ohne DRM
Dieses eBook enthält kein DRM oder Kopier­schutz. Eine Weiter­gabe an Dritte ist jedoch rechtlich nicht zulässig, weil Sie beim Kauf nur die Rechte an der persön­lichen Nutzung erwerben.

Dateiformat: PDF (Portable Document Format)
Mit einem festen Seiten­layout eignet sich die PDF besonders für Fach­bücher mit Spalten, Tabellen und Abbild­ungen. Eine PDF kann auf fast allen Geräten ange­zeigt werden, ist aber für kleine Displays (Smart­phone, eReader) nur einge­schränkt geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich
A Practical Guide for the Food Industry

von Veslemoy Andersen; Huub L. M. Lelieveld; Yasmine Motarjemi

eBook Download (2023)
Elsevier Science (Verlag)
220,00