Arsenic (eBook)
John Wiley & Sons (Verlag)
978-1-118-87659-6 (ISBN)
* Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world
* Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models, and pharmacokinetic and toxicokinetic models
* Discusses outcomes, epidemiology, real-life examples, and modes of action for arsenic-induced diseases, like lung cancer, diabetes, cardiovascular and pulmonary diseases, and immunotoxicity
* Acts as a reference for toxicologists, environmental chemists, and risk assessors and includes up-to-date, novel modeling techniques for scientists
* Includes future perspectives on special topics, like extrapolation from experimental models to human exposures, biomarkers for phenotypic anchoring, and pathology of chronic exposure
J. Christopher States, PhD, is Professor, University Scholar and Vice Chair for Graduate Education in the Department of Pharmacology and Toxicology, and Associate Dean for Research in the University of Louisville School of Medicine, Louisville, Kentucky. He is a Past President of the Society of Toxicology Metals Specialty Section, on the editorial board of several leading journals, and regularly serves as a reviewer of manuscripts and National Institutes of Health grants. He has organized symposia and workshops and chaired sessions on arsenic exposure and toxicology at international conferences and published over 100 articles.
Contributors ix
Preface xiii
Part I Fundamentals of Arsenic Exposure and Metabolism 1
1 History of Arsenic as a Poison and a Medicinal Agent 3
Michael F. Hughes
2 Geogenic and Anthropogenic Arsenic Hazard in Groundwaters and Soils: Distribution, Nature, Origin, and Human Exposure Routes 23
David A. Polya and Michael Lawson
3 Remediation of Arsenic in Drinking Water 61
Cathleen J. Webb and Arden D. Davis
4 The Chemistry and Metabolism of Arsenic 81
David J. Thomas
Part II Epidemiology and Disease Manifestations of Arsenic Exposure 111
5 Human Population Studies and Nutritional Intervention 113
Yu Chen and Fen Wu
6 Skin Manifestations of Chronic Arsenicosis 127
Nilendu Sarma
7 Lung Cancer and Other Pulmonary Diseases 137
Cara L. Sherwood and R. Clark Lantz
8 Bladder Cancer and Arsenic 163
Matthew K. Medeiros and A. Jay Gandolfi
9 Neurological Effects of Arsenic Exposure 193
Dominic B. Fee
10 Diabetes Mellitus 221
Miroslav Styblo and Christelle Douillet
11 Hepatotoxicity 249
Gavin E. Arteel
12 Genetic Epidemiology of Susceptibility to Arsenic-Induced Diseases 267
Mayukh Banerjee and Ashok K. Giri
Part III Mechanisms of Toxicity 289
13 Arsenic Interaction with Zinc Finger Motifs 291
Laurie G. Hudson, Karen L. Cooper, Susan R. Atlas, Brenee S. King and Ke Jian Liu
14 Role in Chemotherapy 315
Koren K. Mann and Maryse Lemaire
15 Genotoxicity 347
Ana Maria Salazar and Patricia Ostrosky-Wegman
16 Arsenic and Signal Transduction 369
Ingrid L. Druwe and Richard R. Vaillancourt
17 Stem Cell Targeting and Alteration by Arsenic 397
Yuanyuan Xu, Erik J. Tokar and Michael P. Waalkes
18 Epigenetics and Arsenic Toxicity 421
Somnath Paul and Pritha Bhattacharjee
Part IV Models for Arsenic Toxicology and Risk Assessment 439
19 Cancer Induced by Exposure to Arsenicals in Animals 441
Erik J. Tokar, Yuanyuan Xu and Michael P. Waalkes
20 Arsenic-Induced Cardiovascular Disease 453
Aaron Barchowsky and J. Christopher States
21 Invertebrate Models in Arsenic Research: Past, Present, and Future 469
Iain L. Cartwright
22 Toxicokinetics and Pharmacokinetic Modeling of Arsenic 495
Elaina M. Kenyon and Harvey J. Clewell, III
23 Considerations for a Biologically Based Risk Assessment for Arsenic 511
Harvey J. Clewell, III, P. Robinan Gentry and Janice W. Yager
24 Translating Experimental Data to Human Populations 535
J. Christopher States
Index 549
Erscheint lt. Verlag | 1.10.2015 |
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Sprache | englisch |
Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie |
Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung | |
Naturwissenschaften ► Chemie ► Anorganische Chemie | |
Technik | |
Schlagworte | Arbeitssicherheit u. Umweltschutz i. d. Chemie • Arsenic, arsenic exposure, arsenic health risks, mechanisms of toxicity, arsenic metabolism, epidemiology and disease, arsenic toxicology, animal models, arsenic risk assessment • Chemical and Environmental Health and Safety • Chemie • Chemistry • Environmental Toxicology • Epidemiologie u. Biostatistik • Epidemiology & Biostatistics • Gesundheits- u. Sozialwesen • Health & Social Care • Umwelttoxikologie |
ISBN-10 | 1-118-87659-8 / 1118876598 |
ISBN-13 | 978-1-118-87659-6 / 9781118876596 |
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