Williams Hematology

Kenneth Kaushansky, MD (Stony Brook, NY) is Senior Vice President, Health Sciences and Dean of the School of Medicine, Stony Brook University. Marshall A. Lichtman, MD (Rochester, NY) is Professor of Medicine and of Biochemistry and Biophysics, University of Rochester Medical Center. Josef T. Prchal, MD (Salt Lake City, UT, and Prague, Czech Republic) is Professor of Medicine, Pathology, and Genetics, Hematology Division of the University of Utah, and Department of Pathophysiology, First Faculty of Medicine, Charles University in Prague. Marcel M. Levi, MD, PhD (Amsterdam, The Netherlands) is Chairman of the Department of Medicine at the Academic Medical Center, University of Amsterdam. Oliver W. Press, MD, PhD (Seattle, WA) is Member and Penny E. Petersen Endowed Chair of Lymphoma Research, Fred Hutchinson Cancer Research Center, Professor of Medicine at the University of Washington. Linda J. Burns, MD (Minneapolis, MN) is Vice President and Medical Director, Health Services Research at National Marrow Donor Program/Be The Match. Michael A. Caligiuri, MD (Columbus, OH) is Director, Comprehensive Cancer Center, CEO, James Cancer Hospital & Solove Research Institute, JL Marakas Nationwide Insurance Enterprise Foundation Chair of Cancer Research, The Ohio State University.

Part 1. Clinical Evaluation of the Patient
1. Initial Approach to the Patient: History and Physical Examination
2. Examination of Blood Cells
3. Examination of The Marrow
4. Consultative Hematology
Part 2. The Organization of the Lymphohematopoietic Tissues
5. Structure of the Marrow and the Hematopoietic Microenvironment
6. The Organization and Structure of Lymphoid Tissues
Part 3. Epochal Hematology
7. Hematology of the Fetus and Newborn
8. Hematology during Pregnancy
9. Hematology in Older Persons
Part 4. Molecular and Cellular Hematology
10. Genetic Principles and Molecular Biology
11. Genomics
12. Epigenetics
13. Cytogenetic and Genetic Abnormalities
14. Metabolism of Hematological Neoplastic Cells
15. Apoptosis and Autophagy
16. Cell cycle regulation and hematological disorders
17. Signal transduction pathways
18. Hematopoietic stem cells, progenitors, and cytokines
19. The inflammatory response
20. Innate immunity
21. Adaptive immunity
Part 5. Therapeutic Principles
22. Pharmacology and toxicity of antineoplastic drugs
23. Hematopoietic stem cell transplantation
24. Treatment of infections in the immunocompromised host
25. Antithrombotic therapy
26. Immune cell therapy
27. Vaccine therapy
28. Therapeutic apheresis: indications, efficacy, and complications
29. Gene transfer for therapy
30. Regenerative Medicine: Multipotential cell therapy for tissue replacement
Part 6. The Erythrocyte
31. Structure and Composition of the Erythrocyte Absorb former 30 Composition of Erythrocyte.
32. Erythropoiesis
33. Erythrocytes turnover
34. Clinical manifestations and classification of erythrocyte disorders
35. Aplastic anemia
36. Pure red cell aplasia
37. Anemia of chronic disease
38. Erythropoietic effects of endocrine disorders
39. The congenital dyserythropoietic anemias
40. Paroxysmal nocturnal hemoglobinuria
41. Folate, cobalamin and megaloblastic anemias
42. Iron Metabolism
43. Iron deficiency and overload
44. Anemia resulting from other nutritional deficiencies
45. Anemia associated with marrow infiltration
46. Erythrocyte Membrane Disorders
47. Erythrocyte Enzyme Disorders
48. The thalassemias
49. Disorders of hemoglobin structure: sickle cell anemia and related abnormalities
50. Methemoglobinemia and other dyshemoglobinemias
51. Fragmentation hemolytic anemia
52. Erythrocyte disorders as a result of chemical and physical agents
53. Hemolytic anemia due to infections with microorganisms
54. Immune Hemolytic Anemia
55. Alloimmune hemolytic disease of the fetus and newborn
56. Hypersplenism and hyposplenism
57. Primary and Secondary Polycythemias
58. The porphyrias
59. Hereditary and acquired (polyclonal) sideroblastic anemias
Part 7. Neutrophils, Eosinophils, Basophils, and Mast Cells
60. Structure and composition of neutrophils, eosinophils, and basophils
Composition of neutrophils
Absorbed into chapter 60
61. Production, distribution, and fate of neutrophils
62. Eosinophils and their disorders
63. Basophils and mast cells, and their disorders
64. Classification and clinical manifestations of neutrophil disorders
65. Neutropenia and neutrophilia
66. Disorders of neutrophil function
Part 8. Monocytes and Macrophages
67. Structure, biochemistry, and function of monocytes and macrophages
Biochemistry and function of monocytes and macrophages ABSORBED
into Chap 67.
68. Production, distribution, and fate of monocytes and macrophages
69. Classification and clinical manifestations of disorders of monocytes and macrophages
70. Monocytosis and monocytopenia
71. Inflammatory and malignant histiocytosis
72. Gaucher Disease and Related Lysosomal Storage Diseases
Part 9. Lymphocytes and Plasma Cells
73. Structure, composition, and biochemistry of lymphocytes and plasma cells
Composition and biochemistry of lymphocytes and plasma cells ABSORBED into Chap 73.
74. Lymphopoiesis
75. Functions of B lymphocytes and plasma cells in immunoglobin production
76. Functions of T lymphocytes: T-cell receptors for antigen
77. Functions of natural killer cells
78. Classification and clinical manifestations of lymphocyte and plasma cell disorders
79. Lymphocytosis and lymphocytopenia
80. Immunodeficiency diseases
81. Hematological manifestations of acquired immunodeficiency syndrome (AIDS)
82. Mononucleosis syndromes
Part 10. Lymphocytes and Plasma Cells
83. Classification and clinical manifestations of the clonal myeloid disorders
84. Polycythemia vera
85. Essential thrombocythemia
86. Primary myelofibrosis
87. Myelodysplastic disorders (Clonal cytopenias and oligoblastic leukemia)
88. Acute Myelogenous Leukemia
89. Chronic Myelogenous Leukemia and Related Disorders
Part 11. Malignant Lymphoid Diseases
90. Classification of Malignant Lymphoid Disorders
91. Acute Lymphoblastic Leukemia
92. Chronic Lymphocytic Leukemia
93. Hairy Cell Leukemia
94. Large Granular Lymphocytic Leukemia
95. General Considerations for Lymphomas: Epidemiology,
Etiology, Heterogeneity, and Primary Extranodal Disease
96. Pathology of Lymphomas
97. Hodgkin Lymphoma
98. Diffuse Large B-Cell Lymphoma and Related Diseases
99. Follicular Lymphoma
100. Mantle Cell Lymphoma
101. Marginal Zone B-Cell Lymphomas
102. Burkitt Lymphoma
103. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome)
104. Mature T-Cell and Natural Killer Cell Lymphomas
105. Plasma Cell Neoplasms: General Considerations
106. Essential Monoclonal Gammopathy
107. Myeloma
108. Immunoglobulin Light-Chain Amyloidosis
109. Macroglobulinemia
110. Heavy-Chain Disease
Part 12. Hemostasis and Thrombosis
111. Megakaryopoiesis and Thrombopoiesis
112. Platelet Morphology, Biochemistry, and Function
113. Molecular Biology and Biochemistry of the
Coagulation Factors and Pathways of Hemostasis
114. Control of Coagulation Reactions
115. Vascular Function in Hemostasis
116. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
117. Thrombocytopenia
118. Heparin-Induced Thrombocytopenia
119. Reactive Thrombocytosis
120. Hereditary Qualitative Platelet Disorders
121. Acquired Qualitative Platelet Disorders
122. The Vascular Purpuras
123. Hemophilia A and Hemophilia B
124. Inherited Deficiencies of Coagulation Factors II, V,V+VIII, VII, X, XI, and XIII
125. Hereditary Fibrinogen Abnormalities
126. von Willebrand Disease
127. Antibody-Mediated Coagulation Factor Deficiencies
128. Hemostatic Alterations in Liver Disease and Liver Transplantation
129. Disseminated Intravascular Coagulation
130. Hereditary Thrombophilia
131. The Antiphospholipid Syndrome
132. Thrombotic Microangiopathies
133. Venous Thrombosis
134. Atherothrombosis: Disease Initiation, Progression, and Treatment
135. Fibrinolysis and Thrombolysis
Part 13. Transfusion Medicine
136. Erythrocyte Antigens and Antibodies
137. Human Leukocyte and Platelet Antigens
138. Blood Procurement and Red Cell Transfusion
139. Preservation and Clinical Use of Platelets
Index