Cardiac Fibrosis and Heart Failure: Cause or Effect? (eBook)

Dr. Jeffrey Wigle is an Associate Professor at the University of Manitoba, Winnipeg, Canada. His research focuses on the transcriptional pathways involved in regulating the growth and development of the cardiovascular system. He has characterized a number of transcription factors that are critical for the development of the lymphatic vasculature and the phenoconversion of fibroblasts to myofibroblasts. He is currently studying the transcriptional feedback loops that determine the fibroblastic phenotype.Dr. Ian M.C. Dixon is a Professor of Physiology and Pathophysiology at the University of Manitoba, Winnipeg, Canada.  His research addresses heart failure following myocardial infarction and the contributing role of dysfunctional extracellular matrix in these hearts. He is also interested in mechanisms of fibroblast phenotype regulation, cardiac fibroblast SMAD protein signaling as well as other signaling proteins that may oppose the fibrogenic influence of TGF-b1 in health and disease. He has been engaged over the past 24 years in multidisciplinary research in cardiovascular matrix biology. 

1. Fibrosis and Heart Failure – Cause or Effect?Ian M.C. Dixon, Ryan H. Cunnington, S.G.  Rattan and J.T. Wigle2. Fibroblast Activation in the Infarcted MyocardiumAmit Saxena and Nicholas Frangogiannis   3. Mechanical and Matrix Regulation of Valvular FibrosisMark C. Blaser and Craig A. Simmons4. Bone Marrow-Derived Progenitor Cells, micro-RNA, and FibrosisAlison L. Muller and Darren H. Freed5. The Stressful Life of Cardiac MyofibroblastsElena Zimina and Boris Hinz6.   Pathogenic Origins of Fibrosis in the Hypertensive Heart Disease that Accompanies AldosteronismR. Justin McCullough, Yao Sun, Kevin P. Newman, Kodangudi B. Ramanathan, Ramareddy V. Guntaka and Karl T. Weber 7. Embryological origin of valve progenitor cellsMichel Pucéat & Thomas Moore-Morris8. Diverse cellular origins of cardiac fibroblastsFahmida Jahan and Jeffrey T. Wigle9. Non-Canonical Regulation of TGF-β1 Signaling: A Role for Ski/Sno and YAP/TAZMathew R.  Zeglinski, Natalie Landry and Ian M.C. Dixon10. Molecular mechanisms of smooth muscle and fibroblast phenotype conversions in the failing heartChristina Pagiatakis and John C. McDermott,11. Current and future strategies for the diagnosis and treatment of cardiac fibrosis.Patricia Roche and Michael P. Czubryt12. Remodelling of the cardiac extracellular matrix:  Role of collagen degradation and accumulation in  pathogenesis of heart failureAbhijit Takawale, Mengcheng Shen, Dong Fan, Zamaneh Kassiri13. Matrix Metalloproteinase 9 (MMP-9): The Middle-Man of Post Myocardial Infarction Extracellular Matrix RemodellingFouad A. Zouein, Ashley Decoux1, Yuan Tian1, Jared White, Yu-Fang Jin and and Merry L. Lindsey14.  Collagen processing and its role in FibrosisChristopher A. McCulloch and Nuno M. Coelho 15. Mechanisms of Cardiac FibrosisKeith Dadson, Vera Kovacevic and Gary Sweeney16. Mathematical Simulations of Sphingosine-1-Phosphate Actions on Mammalian Ventricular Myofibroblasts and MyocytesK. A. MacCannell, L. Chilton, G. L. Smith, and W. R. Giles17. Extracellular Matrix and Cardiac Disease:Surgical and Scientific PerspectivesHolly Mewhort and Paul Fedak18. The Role of Neurohumoral Activation in Cardiac Fibrosis and Heart FailureNirmal Parajuli, Tharmarajan Ramprasath, Pavel Zhabyeyev, Vaibhav B. Patel and Gavin Y. Oudit19. Natriuretic peptides: critical regulators of cardiac fibroblasts and the extracellular matrix in the heartHailey J. Jansen and Robert A. Rose20.  Cardiac Tissue Engineering for the Treatment of Heart Failure Post-InfarctionJacqueline S. Wendel, Robert. T Tranquillo21.  Mechanisms of Cardiac Valve Failure and the Development of Tissue Engineered Heart ValvesMeghana R.K. Helder and Robert D. Simari