Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies -

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies (eBook)

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2014 | 1. Auflage
520 Seiten
Elsevier Science (Verlag)
978-0-12-416661-5 (ISBN)
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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies.
  • Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy
  • Highlights novel cases from current clinical trials as well as marketed products
  • Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

List of Contributors


Reinaldo Acevedo,     Research and Development vice-presidency of Finlay Institute, Havana, Cuba

Juan C. Almagro,     CTI-Boston, Pfizer, Inc., Boston, MA, USA

Manal Alsaadi,     University of Tripoli, Faculty of Pharmacy, Tripoli, Libya

Chantal C.M. Appeldoorn,     to-BBB Technologies B.V., Leiden, The Netherlands

Alexandra Beumer Sassi,     Biopharm R&D, GlaxoSmithKline, King of Prussia, PA, USA

Akhilesh Bhambhani,     Merck Research Laboratories, Bioprocess R&D, Formulation Development, West Point, PA, USA

Catherine M. Bollard,     Children’s National Health System, Washington DC, USA

Kim Braz-Gomes,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Randall J. Brezski,     Principal Scientist, Biologics Research, Janssen R&D, LLC, USA

Andrew Buchanan,     Antibody Discovery and Protein Engineering, MedImmune, Cambridge, UK

Danilo Casimiro,     Merck Research Laboratories, Vaccine Research, West Point, PA, USA

Divya Chandra,     Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA

Maurizio Chiriva-Internati,     Texas Tech University, Health Science Center, Lubbock, TX, USA

Beth-Ann Coller,     Merck Research Laboratories, Vaccine Research, Global Clinical Development, North Wales, PA, USA

Conrad Russell Y. Cruz,     Children’s National Health System, Washington DC, USA

Marco de Boer,     to-BBB Technologies B.V., Leiden, The Netherlands

Robert De Rose,     Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia

Sucheta D’Sa,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Bernadette D’Souza,     Department of Pharmaceutical Sciences, McWhorter School of Pharmacy, Social and Administrative Sciences, Samford University, Birmingham, AL, USA

Marissa D’Souza

Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Georgia Institute of Technology, Biomedical Engineering Program, Atlanta, GA, USA

Martin J. D’Souza,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Nigel D’Souza,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Mauro Ferrari

Houston Methodist Research Institute, Houston, TX, USA

Weill Cornell Medical College, New York, NY, USA

Valerie A. Ferro,     University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK

Pieter J. Gaillard,     to-BBB Technologies B.V., Leiden, The Netherlands

Rikhav P. Gala,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Deborah A. Garside,     Imperial College London, Faculty of Medicine, London, UK

Ayman Gebril,     University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK

Werner Gladdines,     to-BBB Technologies B.V., Leiden, The Netherlands

Ana Maria Gonzalez-Angulo,     Department of Breast Medical Oncology, Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

Paul Hamblin,     Biopharm R&D, GlaxoSmithKline, King of Prussia, PA, USA

Qing-Yu He,     Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China

Jon Heinrichs,     Merck Research Laboratories, Vaccine Research, West Point, PA, USA

Erica Jackson,     College of Medicine, University of South Florida, Tampa, FL, USA

Pankaj Karande,     Howard P. Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA

Stephen J. Kent,     Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia

Sreekumar Kodangattil,     CTI-Boston, Pfizer, Inc., Boston, MA, USA

Dimitrios Lamprou,     University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK

Kenneth Lundstrom,     Pan Therapeutics, Lutry, Switzerland

Sara Movassaghian,     Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA

Nihal S. Mulla,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Alexander B. Mullen,     University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK

Radhika Nagarkar,     Biopharmaceutical Development, KBI Biopharma, Inc., Durham, NC, USA

Lakshmy Nair,     Department of Breast Medical Oncology, Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

Natalie Nimmo,     University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Science, Glasgow, UK

Ashwin C. Parenky,     Mercer University, College of Pharmacy, Vaccine Nanotechnology Laboratory, Atlanta, GA, USA

Brianna Oliver,     College of Medicine, University of South Florida, Tampa, FL, USA

Ernesto Oviedo-Orta,     Novartis Vaccines and Diagnostics, Vaccines Research, Siena, Italy

Teresa Ramirez-Montagut,     Genomics Institute of the Novartis Research Foundation, San Diego, CA, USA

Charani Ranasinghe,     John Curtin School of Medical Research, Australian National University, Canberra, Australia

Arie Reijerkerk,     to-BBB Technologies B.V., Leiden, The Netherlands

Jefferson D. Revell,     Antibody Discovery and Protein Engineering, MedImmune, Cambridge, UK

Jaap Rip,     to-BBB Technologies B.V., Leiden, The Netherlands

Haifa Shen

Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA

Weill Cornell Medical College, New York, NY, USA

Hatem Soliman,     Moffitt Cancer Center and Research Institute, Women’s Oncology and Experimental Therapeutics, Tampa, FL, USA

Bin Sun

Southern Medical University

Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China

Krishna Suri,     Houston Methodist Research Institute, Houston, TX, USA

Jan ter Meulen,     Immune Design, Seattle, WA, USA

Vladimir P. Torchilin,     Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University,...

Erscheint lt. Verlag 30.12.2014
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Studium Querschnittsbereiche Infektiologie / Immunologie
Technik
Wirtschaft
ISBN-10 0-12-416661-X / 012416661X
ISBN-13 978-0-12-416661-5 / 9780124166615
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