Statistical Methods for Dynamic Treatment Regimes

Bibhas Chakraborty is an Assistant Professor of Biostatistics at the Mailman School of Public Health, Columbia University. His primary research interests lie in dynamic treatment regimes, machine learning and data mining including reinforcement learning, causal inference, and design and analysis of clinical trials. He received a Bachelor’s degree from the University of Calcutta, a Master’s degree from the Indian Statistical Institute, and a Ph.D. in Statistics from the University of Michigan. He is the recipient of the Calderone Research Prize for Junior Faculty from the Mailman School of Public Health, Columbia University, in 2011. Erica Moodie is an Associate Professor of Biostatistics in the Department of Epidemiology, Biostatistics, and Occupational Health at McGill University. Her main interests lie in causal inference and longitudinal data with a focus on methods for HIV research. She is an Associate Editor of The International Journal of Biostatistics and Journal of Causal Inference. She received a bachelor's degree in Mathematics and Statistics from the University of Winnipeg, an M.Phil. in Epidemiology from the University of Cambridge, and a Ph.D. in Biostatistics from the University of Washington. She is the recipient of a Natural Sciences and Engineering Research Council University Faculty Award.

Introduction.- The Data: Observational Studies and Sequentially Randomized Trials.- Statistical Reinforcement Learning.- Estimation of Optimal DTRs by Modeling Contrasts of Conditional Mean Outcomes.- Estimation of Optimal DTRs by Directly Modeling Regimes.- G-computation: Parametric Estimation of Optimal DTRs.- Estimation DTRs for Alternative Outcome Types.- Inference and Non-regularity.- Additional Considerations and Final Thoughts.- Glossary.- Index.- References.