- Provides analysis of biofilms and their relevance to implant associated infections.
- Assesses technologies for controlling biofilms.
- Considers advantages and disadvantages of in vivo infection studies.
Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection. Provides analysis of biofilms and their relevance to implant associated infections. Assesses technologies for controlling biofilms. Considers advantages and disadvantages of in vivo infection studies.
Cover 1
Biomaterials and Medical Device-associated Infections 4
Copyright 5
Contents 6
List of contributors 10
Woodhead Publishing Series in Biomaterials 12
Part One Introduction to biomaterials and medical device-related infections 16
1 Introduction to biomaterials and medical device-associated infections 18
1.1 History of biomaterials 18
1.2 Overview of current medical devices and applications 20
1.3 Overview of problems associated with medical devices 22
1.4 Introduction to the structure of this book 28
References 29
2 Biofilms and implant-associated infections 34
2.1 Introduction 34
2.2 Microbial profile of implant-associated infections 34
2.3 Relevance of biofilms in implant-associated infections 38
2.4 Structure and composition of biofilms 39
2.5 Pathogenesis of biofilm infection 41
2.6 Future trends 51
2.7 Further information and advice 51
References 52
3 In vivo infection studies 62
3.1 Introduction 62
3.2 Legitimacy of animal studies 63
3.3 Choosing the right animal model to study device-associated infections 64
3.4 Pros and cons of in vivo infection studies 75
3.5 Correlation of outcome between animal and clinical studies 77
3.6 Conclusion and future trends 78
3.7 Sources of further information and advice 78
Acknowledgments 79
References 79
4 Diagnosis of biofilm-associated infections in medical devices 86
4.1 Introduction 86
4.2 Importance of detection of biofilm 87
4.3 Sites of biofilm formation 88
4.4 Collection of samples for biofilm detection 88
4.5 Examples of methods for the detection of biofilms associated with infections 89
4.6 Future trends 93
4.7 Conclusion 94
Acknowledgement 94
References 94
5 Diagnosis and treatment of implant-associated infections 98
5.1 Introduction 98
5.2 Risk factors and prevention 99
5.3 Diagnosis 102
5.4 Treatment 103
5.5 Future trends 111
References 111
Part Two Technologies and materials for controlling biofilms 116
6 Surface modification of biomaterials for biofilm control 118
6.1 Introduction 118
6.2 Principles of bacterial cell–biomaterial surface interactions 118
6.3 Substrate specific biological response 120
6.4 Looking at nature for inspiration 121
6.5 Modifications to prevent initial stages of bacterial adhesion 122
6.6 Methods to prevent irreversible attachment of microorganisms 124
6.7 Mitigation of biofilm formation by attached organisms 125
6.8 Future trends 138
References 139
7 Surface nanoengineering for combating biomaterials infections 148
7.1 Introduction 148
7.2 Modification of surface nano topography to inhibit bacterial adhesion 149
7.3 Surface functionalization with eluting antibacterial agent 151
7.4 Surface functionalization with anti-adhesive polymers 155
7.5 Immobilization of bactericidal moieties on surfaces 161
7.6 Conclusion and future trends 167
7.7 Sources of further information and advice 168
References 168
8 Bioactive biomaterials for controlling biofilms 178
8.1 Introduction 178
8.2 Definition of medical device 180
8.3 Biomaterials 180
8.4 Biomaterial applications in medical devices 182
8.5 Post-implantation device-associated infections 186
8.6 Development of conventional antimicrobial biomaterials 188
8.7 Conclusion 195
References 195
9 Antibiotics and cements for the prevention of biofilm-associated infections 200
9.1 Introduction 200
9.2 Biomaterials, infections and orthopedics 200
9.3 History of antibiotic-loaded bone cement (ALBC) 201
9.4 Indication of ALBC 201
9.5 Method of mixing the ALBC 202
9.6 The choice of antibiotic, its dosage and associations of different drugs 203
9.7 The antibiotic release 206
9.8 Mechanical properties of ALBC 207
9.9 Toxicity 208
9.10 Conclusion 208
References 209
10 Antibacterial composite restorative materials for dental applications 214
10.1 Introduction 214
10.2 Current direct aesthetic restorative materials 215
10.3 Antibacterial properties of aesthetic restorative materials 216
10.4 Re-mineralizing dental composites 221
10.5 Antibacterial, remineralizing and proteinases inhibiting materials 223
10.6 Conclusion and future trends 228
References 228
11 Infection resistant biomaterials 238
11.1 Introduction 238
11.2 History 239
11.3 Drug-releasing antimicrobial systems 240
11.4 Antimicrobial cationic systems 246
11.5 Antifouling surfaces 249
11.6 Naturally occurring antifouling surfaces 253
11.7 Silver ions and silver-containing surfaces 255
11.8 Conclusion 257
References 257
Appendix: abbreviations 269
Index 270
Woodhead Publishing Series in Biomaterials
1 Sterilisation of tissues using ionising radiations
Edited by J. F. Kennedy, G. O. Phillips and P. A. Williams
2 Surfaces and interfaces for biomaterials
Edited by P. Vadgama
3 Molecular interfacial phenomena of polymers and biopolymers
Edited by C. Chen
4 Biomaterials, artificial organs and tissue engineering
Edited by L. Hench and J. Jones
5 Medical modelling
R. Bibb
6 Artificial cells, cell engineering and therapy
Edited by S. Prakash
7 Biomedical polymers
Edited by M. Jenkins
8 Tissue engineering using ceramics and polymers
Edited by A. R. Boccaccini and J. Gough
9 Bioceramics and their clinical applications
Edited by T. Kokubo
10 Dental biomaterials
Edited by R. V. Curtis and T. F. Watson
11 Joint replacement technology
Edited by P. A. Revell
12 Natural-based polymers for biomedical applications
Edited by R. L. Reiss et al.,
13 Degradation rate of bioresorbable materials
Edited by F. J. Buchanan
14 Orthopaedic bone cements
Edited by S. Deb
15 Shape memory alloys for biomedical applications
Edited by T. Yoneyama and S. Miyazaki
16 Cellular response to biomaterials
Edited by L. Di Silvio
17 Biomaterials for treating skin loss
Edited by D. P. Orgill and C. Blanco
18 Biomaterials and tissue engineering in urology
Edited by J.Denstedt and A. Atala
19 Materials science for dentistry
B. W. Darvell
20 Bone repair biomaterials
Edited by J. A. Planell, S. M. Best, D. Lacroix and A. Merolli
21 Biomedical composites
Edited by L. Ambrosio
22 Drug–device combination products
Edited by A. Lewis
23 Biomaterials and regenerative medicine in ophthalmology
Edited by T. V. Chirila
24 Regenerative medicine and biomaterials for the repair of connective tissues
Edited by C. Archer and J. Ralphs
25 Metals for biomedical devices
Edited by M. Ninomi
26 Biointegration of medical implant materials: Science and design
Edited by C. P. Sharma
27 Biomaterials and devices for the circulatory system
Edited by T. Gourlay and R. Black
28 Surface modification of biomaterials: Methods analysis and applications
Edited by R. Williams
29 Biomaterials for artificial organs
Edited by M. Lysaght and T. Webster
30 Injectable biomaterials: Science and applications
Edited by B. Vernon
31 Biomedical hydrogels: Biochemistry, manufacture and medical applications
Edited by S. Rimmer
32 Preprosthetic and maxillofacial surgery: Biomaterials, bone grafting and tissue engineering
Edited by J. Ferri and E. Hunziker
33 Bioactive materials in medicine: Design and applications
Edited by X. Zhao, J. M. Courtney and H. Qian
34 Advanced wound repair therapies
Edited by D. Farrar
35 Electrospinning for tissue regeneration
Edited by L. Bosworth and S. Downes
36 Bioactive glasses: Materials, properties and applications
Edited by H. O. Ylänen
37 Coatings for biomedical applications
Edited by M. Driver
38 Progenitor and stem cell technologies and therapies
Edited by A. Atala
39 Biomaterials for spinal surgery
Edited by L. Ambrosio and E. Tanner
40 Minimized cardiopulmonary bypass techniques and technologies
Edited by T. Gourlay and S. Gunaydin
41 Wear of orthopaedic implants and artificial joints
Edited by S. Affatato
42 Biomaterials in plastic surgery: Breast implants
Edited by W. Peters, H. Brandon, K. L. Jerina, C. Wolf and V. L. Young
43 MEMS for biomedical applications
Edited by S. Bhansali and A. Vasudev
44 Durability and reliability of medical polymers
Edited by M. Jenkins and A. Stamboulis
45 Biosensors for medical applications
Edited by S. Higson
46 Sterilisation of biomaterials and medical devices
Edited by S. Lerouge and A. Simmons
47 The hip resurfacing handbook: A practical guide to the use and management of modern hip resurfacings
Edited by K. De Smet, P. Campbell and C. Van Der Straeten
48 Developments in tissue engineered and regenerative medicine products
J. Basu and J. W. Ludlow
49 Nanomedicine: Technologies and applications
Edited by T. J. Webster
50 Biocompatibility and performance of medical devices
Edited by J-P. Boutrand
51 Medical robotics: Minimally invasive surgery
Edited by P. Gomes
52 Implantable sensor systems for medical applications
Edited by A. Inmann and D. Hodgins
53 Non-metallic biomaterials for tooth repair and replacement
Edited by P. Vallittu
54 Joining and assembly of medical materials and devices
Edited by Y. (Norman) Zhou and M. D. Breyen
55 Diamond-based materials for biomedical applications
Edited by R. Narayan
56 Nanomaterials in tissue engineering: Fabrication and applications
Edited by A. K. Gaharwar, S. Sant, M. J. Hancock and S. A. Hacking
57 Biomimetic biomaterials: Structure and applications
Edited by A. J. Ruys
58 Standardisation in cell and tissue engineering: Methods and protocols
Edited by V. Salih
59 Inhaler devices: Fundamentals, design and drug delivery
Edited by P. Prokopovich
60 Bio-tribocorrosion in biomaterials and medical implants
Edited by Y. Yan
61 Microfluidic devices for biomedical applications
Edited by X-J. James Li and Y. Zhou
62 Decontamination in hospitals and...
| Erscheint lt. Verlag | 21.11.2014 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Technik ► Medizintechnik | |
| ISBN-10 | 0-85709-722-9 / 0857097229 |
| ISBN-13 | 978-0-85709-722-4 / 9780857097224 |
| Haben Sie eine Frage zum Produkt? |
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