Natural Products Analysis (eBook)

Vladimir Havlicek is a Professor of Analytical Chemistry in the Institute of Microbiology of the Academy of Sciences of the Czech Republic. His laboratory uses analytical tools to characterize molecular structure. He has worked in the field of natural products for over 20 years. Dr. Havlicek is on the editorial or advisory boards of several leading analytical journals and has published over 130 papers in peer-reviewed journals. Jaroslav Spizek is a Professor of Molecular and Cell Biology and Genetics in the Institute of Microbiology of the Academy of Sciences of the Czech Republic, where he was director between1992-2000. He has worked in the field of antibiotics for 50 years. In 2011, he became an Elected Fellow of the American Academy of Microbiology. Professor Spizek has published 98 peer-reviewed papers and edited two books.

Preface ix

Contributors xi

1. Natural Products Analysis: Instrumentation, Methods, and
Applications 1

Vladimír Havlíèek and Jaroslav
Spí?ek

2. The Need for New Antifungal and Antimalarial Compounds
9

Jaroslav Spí?ek and Arnold L. Demain

3. Emerging Instrumental Methods for Antimicrobial Resistance
and Virulence Testing 25

Plamen A. Demirev

4. Plant and Marine Sources: Biological Activity of Natural
Products and Therapeutic Use 43

Amedeo Amedei and Elena Niccolai

5. Emerging Trends for Stimulating the Discovery of Natural
Products 115

Navid Adnani, Gregory A. Ellis, Thomas P. Wyche, Tim S. Bugni,
Jason C. Kwan, and Eric W. Schmidt

6. Advances and Challenges in Optical Molecular Spectroscopy
Including Surface Plasmon Resonance-Based Methods for Bioanalysis
163

Pavel Matìjka, Blanka Vlèková, Lucie
Bednárová, and Petr Malon

7. Advanced Techniques for NMR Analysis of Complex Biological
Mixtures--From Simple NMR to Hyphenated Techniques 239

Helena Pelantová, Simona Bártová, and Marek
Kuzma

8. Advances in X-Ray Diffraction: Implications to the
Pharmaceutical Industry 285

Alexandr Jegorov and Michal HuSák

9. Laser Ablation Inductively Coupled Plasma Mass Spectrometry
as a Tool in Biological Sciences 313

Michaela VaSinová Galiová, Jan HavliS, and
Viktor Kanicky

10. Imaging Mass Spectrometry, Metabolism, and New Views of the
Microbial World 349

B. Christopher Hoefler and Paul D. Straight

11. Structural Separations for Natural Product Characterization
by Ion Mobility-Mass Spectrometry: Fundamental Theory to
Emerging Applications 397

Sarah M. Stow, Nichole M. Lareau, Kelly M. Hines, C. Ruth
McNees, Cody R. Goodwin, Brian O. Bachmann, and John A.
McLean

12. High-Resolution Tandem Mass Spectrometry for Nonribosomal
Peptide and Polyketide Analysis 433

Rebecca H. Wills, Manuela Tosin, and Peter B.
O'Connor

13. Natural Product Drug Discovery and Analysis Using Mass
Spectrometry and Affinity-Based Technologies 475

Evelyn H. Wang and Kevin A. Schug

14. Glycosylated Ribosomally Synthesized Peptide Toxins:
Discovery, Characterization, and Applications 507

Gillian E. Norris and Mark L. Patchett

15. Using Ultrahigh-Resolution Mass Spectrometry to Unravel the
Chemical Space of Complex Natural Product Mixtures 545

Constanze Müller, Mourad Harir, Norbert Hertkorn, Basem
Kanawati, Dimitrios Tziotis, and Philippe Schmitt-Kopplin

16. Functional Amyloid Fibrils: Lessons from Microbes 571

Sally L. Gras and Dennis Claessen

Index 601

"Every chapter, even those that depart somewhat from the declared remit, is packed with information most of it, as I said at the beginning, representing the cutting edge of the subject. I cannot recommend it too highly." (Chromatographia, 1 May 2015)