Perinatal Stem Cells (eBook)

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2014 | 2014
XXIII, 373 Seiten
Springer New York (Verlag)
978-1-4939-1118-9 (ISBN)

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This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology,  and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book, readers will gain a thorough understanding of the current pre-clinical and clinical applications of perinatal stem cells as well as the efforts to support the transition of perinatal stem cell therapies from laboratories to clinics.

Perinatal Stem Cells contains thirty-two chapters written by internationally recognized leaders in stem cell research. It is organized into four sections covering amniotic fluid stem cells, placental and placental membrane stem cells, umbilical cord stem cells, and clinical translation. This cohesive structure provides an effective framework for detailed insight into this new frontier. Edited by Dr. Anthony Atala, one of the foremost experts in the field, and his co-editor Dr. Sean V. Murphy, this volume is a definitive work for stem cell research and its future implications. It is a key resource for all stem cell researchers, clinicians, and government and industry staff working in this dynamic and exciting field.



Dr. Anthony Atala is widely recognized as a true groundbreaker in stem cell research and regenerative medicine. He led the team that grew the first lab-grown organ to be implanted into a human. Aside from being involved in many of the field's top journals, he has devoted the last several decades of his career to the development of sustainable organs grown from a patient's own stem cells - technology that has the potential to solve the problem of patients dying while waiting for organs as well as the common organ transplant complication of rejection. Dr. Atala received a bachelor's degree in psychology from the University of Miami and his medical degree from the University of Louisville, where he completed his residency in urology. While a Fellow at Harvard Medical School, he trained with renowned pediatric urologic surgeons and eventually became Director of the Laboratory for Tissue Engineering and Cellular Therapeutics at Children's Hospital Boston, where his work involved the growing of human tissue and organs to replace those damaged through disease or defect. After that, Dr. Atala moved to Wake Forest, and it was there that he and his team developed the lab-grown bladder that was implanted in a human. A prolific author and editor of journal articles and books, Dr. Atala is the recipient of multiple awards and patents, presented an ovation-receiving TED lecture, and has been featured on 60 Minutes. His accomplishments also include being ranked as the 56th most influential person of the year in a Time Magazine poll and being ranked by Esquire Magazine as one of the 75 most influential persons of the 21st century.

Dr. Sean V. Murphy received his Ph.D. from Monash University, Melbourne, Australia and is currently a Research Fellow at the Wake Forest Institute for Regenerative Medicine in North Carolina, USA. His research focuses on the clinical application of perinatal cells and tissues for the treatment of injury and disease. Dr. Murphy has received numerous awards and fellowships, most notably an American Lung Association Senior Research Training Fellowship, and an American Australian Association Sir Keith Murdoch Fellowship. Dr. Murphy is Director/Secretary and Founder of the International Perinatal Stem Cell Society, Chair of the Scientific & Professional Development Committee for the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and serves on the editorial board of multiple international journals.


This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology, and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book, readers will gain a thorough understanding of the current pre-clinical and clinical applications of perinatal stem cells as well as the efforts to support the transition of perinatal stem cell therapies from laboratories to clinics.Perinatal Stem Cells contains thirty-two chapters written by internationally recognized leaders in stem cell research. It is organized into four sections covering amniotic fluid stem cells, placental and placental membrane stem cells, umbilical cord stem cells, and clinical translation. This cohesive structure provides an effective framework for detailed insight into this new frontier. Edited by Dr. Anthony Atala, one of the foremost experts in the field, and his co-editor Dr. Sean V. Murphy, this volume is a definitive work for stem cell research and its future implications. It is a key resource for all stem cell researchers, clinicians, and government and industry staff working in this dynamic and exciting field.

Dr. Anthony Atala is widely recognized as a true groundbreaker in stem cell research and regenerative medicine. He led the team that grew the first lab-grown organ to be implanted into a human. Aside from being involved in many of the field’s top journals, he has devoted the last several decades of his career to the development of sustainable organs grown from a patient’s own stem cells – technology that has the potential to solve the problem of patients dying while waiting for organs as well as the common organ transplant complication of rejection. Dr. Atala received a bachelor’s degree in psychology from the University of Miami and his medical degree from the University of Louisville, where he completed his residency in urology. While a Fellow at Harvard Medical School, he trained with renowned pediatric urologic surgeons and eventually became Director of the Laboratory for Tissue Engineering and Cellular Therapeutics at Children's Hospital Boston, where his work involved the growing of human tissue and organs to replace those damaged through disease or defect. After that, Dr. Atala moved to Wake Forest, and it was there that he and his team developed the lab-grown bladder that was implanted in a human. A prolific author and editor of journal articles and books, Dr. Atala is the recipient of multiple awards and patents, presented an ovation-receiving TED lecture, and has been featured on 60 Minutes. His accomplishments also include being ranked as the 56th most influential person of the year in a Time Magazine poll and being ranked by Esquire Magazine as one of the 75 most influential persons of the 21st century.Dr. Sean V. Murphy received his Ph.D. from Monash University, Melbourne, Australia and is currently a Research Fellow at the Wake Forest Institute for Regenerative Medicine in North Carolina, USA. His research focuses on the clinical application of perinatal cells and tissues for the treatment of injury and disease. Dr. Murphy has received numerous awards and fellowships, most notably an American Lung Association Senior Research Training Fellowship, and an American Australian Association Sir Keith Murdoch Fellowship. Dr. Murphy is Director/Secretary and Founder of the International Perinatal Stem Cell Society, Chair of the Scientific & Professional Development Committee for the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and serves on the editorial board of multiple international journals.

.- 1 Amniotic Fluid Stem Cells for Cardiac Regeneration  .- Sveva Bollini, Michela Pozzobon, Nicola Smart and Paolo De Coppi .- 2 Amniotic Fluid Stem Cells for Wound Healing  .- Aleksander Skardal .- 3 Treatment of Necrotising Enterocolitis (NEC) with Amniotic Fluid Stem Cells  .- Augusto Zani, Mara Cananzi, Simon Eaton and Paolo De Coppi .- 4 Therapeutic Application of Amniotic Fluid Stem Cells for Graft-versus-Host Disease              .- Emily C. Moorefield, Mark E. Furth and Colin E. Bishop .- 5 Amniotic Fluid Stem Cell Features Supporting their Putative Role in Fetal Cell Microchimerism  .- Margit Rosner, Katharina Schipany and Markus Hengstschläger .- 6 Amniotic Fluid Stem Cell Therapy for Lung Disease  .- Orquidea Garcia and David Warburton .- 7 Direct Reprogramming of Amniotic Cells into Endothelial Cells  .- Koji Shido, Joseph M. Scandura and Shahin Rafii .- 8 Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects  .- Andrea Preitschopf, Julia Busch, Hannes Zwickl, Markus Hengstschläger and Mario Mikula .- 9 Amniotic Fluid-Derived Cells: An Autologous Cell Source for Cardiovascular Tissue Engineering  .- Benedikt Weber, Debora Kehl and Simon P. Hoerstup .- 10 Amniotic Fluid Stem Cells for Bone Tissue Engineering  .- Jaehyun Kim, Sookwon Ryu, Young Min Ju, James Yoo and Anthony Atala .- 11 Amniotic Fluid Stem Cells for the Repair of Prenatal and Perinatal Defects  .- Weerapong Prasongchean and Patrizia Ferretti .- 12 Stimulation of Therapeutic Angiogenesis Using Amniotic Fluid Stem Cells  .- Teodelinda Mirabella .- 13 Placental Stem/Progenitor Cells: Isolation and Characterization  .- Ornella Parolini, Debashree De, Melissa Rodrigues and Maddalena Caruso .- 14 Treatment of Liver Disease using Placental Stem Cells: Feasibility of Placental Stem Cells in Liver Diseases: Potential Implication of New Cell Therapy-Based Strategies for Hepatic Diseases .- Gi Jin Kim .- 15 The Human Term Placenta as a Source of Transplantable Hematopoietic Stem Cells              .- Alicia Bárcena, Marcus O. Muench, Mirhan Kapidzic, Matthew Gormley and Susan J. Fisher .- 16 Placental Stem Cells for Cartilage Tissue Engineering  .- Hsi-Yi Yeh, Betty Linju Yen and Shan-hui Hsu .- 17 Mesenchymal Stem Cells from Human Amniotic Membrane  .- Clara Sanjurjo Rodriguez, Silvia Diaz-Prado, Tamara Hermida-Gómez, Isaac Fuentes-Boquete and Francisco J. Blanco .- 18 Bladder Reconstruction Using Amniotic Mesenchymal Stem Cells  .- Tomonori Minagawa, Tetsuya Imamura, Osamu Ishizuka and Osamu Nishizawa .- 19 Amnion Epithelial Cells for Lung Diseases  .- Euan M. Wallace, Jean L. Tan, Atul Malhotra, Graham Jenkin and Rebecca Lim .- 20 Potential Efficacy of Amnion Epithelial Cells to Treat Post-Stroke Inflammation  .- Brad RS Broughton, Rebecca Lim, Megan A. Evans, Grant R Drummond, Euan M. Wallace and Christopher G. Sobey .- 21 The Potential of Human Amnion Epithelial Cells as an Immunomodulatory and Neuroregenerative Treatment for Multiple Sclerosis  .- Courtney A. McDonald, Martin Short, Graham Jenkin and Claude Charles Andre Bernard .- 22 Human Amniotic Epithelial Cells Transplantation for Contusive Spinal Cord Injury Repair  .- Prem Kumar Jayapal, Sridharan Neelamegan, Tamilselvi Palaniappan, Sridhar Skylab Rajan, Vijaya Prakash Krishnan Muthiah and Sankar Venkatachalam .- 23 Therapeutic Potential of Amnion Epithelial Cells for Diabetes  .- Chika Koike, Motonori Okabe, Toshiko Yoshida and Toshio Nikaido .- 24 Collection, Processing & Banking of Umbilical Cord Blood  .- David T. Harris .- 25 Umbilical Cord Blood Cells in the Repair of Central Nervous System Diseases  .- Paul R. Sanberg, David J. Eve and Cesar V. Borlongan .- 26 Umbilical Cord Blood for Cardiovascular Cell Therapy  .- Santiago Roura Ferrer, Carolina Gálvez-Montón and Antoni Bayés-Genis .- 27 Bone Regeneration using Wharton's Jelly Mesenchymal Stem Cells  .- Kyoko Baba, Yasuharu Yamazaki, Akira Takeda and Eiju Uchinuma .- 28 Wharton's Jelly Mesenchymal Stem Cells for the Treatment of Type 1 Diabetes  .- Rita Anzalone, Melania Lo Iacono, Tiziana Corsello, Cristiana Rastellini, Luca Cicalese, Felicia Farina and Giampiero La Rocca .- 29 Umbilical Cord Blood-Derived Endothelial Progenitor Cells for Cardiovascular Tissue Engineering  .- Benedikt Weber, Zeisberger M. Steffen and Hoerstrup P. Simon .- 30 Manufacturing Perinatal Stem Cells for Clinical Applications  .- Celena Heazlewood, Nina Iliac and Kerry Atkinson .- 31 Towards Clinical Applications of Umbilical Cord Derived Mesenchymal Stem Cells              .- Rouzbeh R. Taghizadeh, Paul W. Holzer, Teresa Marino, Kyle J. Cetrulo, Curtis L. Cetrulo, Sr. and Curtis L. Cetrulo, Jr. .- 32 Recent Patents on Perinatal Stem Cells  .- Tamara Yawno, Euan M. Wallace and Rebecca Lim.

Erscheint lt. Verlag 28.8.2014
Zusatzinfo XXIII, 373 p. 101 illus., 87 illus. in color.
Verlagsort New York
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Gynäkologie / Geburtshilfe
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Studium 1. Studienabschnitt (Vorklinik) Histologie / Embryologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte amniotic fluid • Cord blood • hematopoietic cells • mesenchymal cells • Progenitor Cells • wharton's jelly
ISBN-10 1-4939-1118-X / 149391118X
ISBN-13 978-1-4939-1118-9 / 9781493911189
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