Drug Delivery Applications of Noninvasive Imaging (eBook)

CHUN LI, PhD, is Professor and Ad Interim Chief, Chemistry Section, in the Department of Cancer Systems Imaging at the University of Texas MD Anderson Cancer Center. He is Associate Editor of Cancer Nanotechnology and a member of the editorial boards of American Journal of Nuclear Medicine and Molecular Imaging and Quantitative Imaging in Medicine and Surgery. Dr. Li has more than 120 peer-reviewed publications and holds twenty-eight patents. MEI TIAN, MD, is Vice President of Hangzhou Binjiang Hospital and Professor of Diagnostic Imaging and Nuclear Medicine at The Second Hospital, Zhejiang University School of Medicine. Dr. Tian is also an editorial consultant for The Lancet. She is a member of the editorial boards of Journal of Nuclear Medicine, European Journal of Nuclear Medicine and Molecular Imaging, Nuclear Medicine Communications, and Oncology.

Preface ix

contributors xi

1 Introduction to Molecular Imaging 1

Vikas Kundra

2 PET/SPECT: Instrumentation and Imaging Techniques 12

Yuan-Chuan Tai

3 Photoacoustic Tomography and Its Applications in Drug Delivery
and Photothermal Therapy 45

Liang Song and Lihong V. Wang

4 Raman Microspectral Imaging for Label-Free Detection of
Nanoparticle-Mediated Cellular and Subcellular Drug Delivery
70

Tatyana Chernenko, Lara Milane, Christian Matthäus, Max
Diem, and Mansoor Amiji

5 A natomical and Functional MRI91

Edward F. Jackson

6 Quantitative Imaging in Drug Delivery 125

Kooresh I. Shoghi

7 PET Imaging of the Pharmacokinetics of Small Molecular-Weight
Drugs 147

Stephen M. Moerlein and Zhude Tu

8 Imaging Peptides, Proteins, and Antibody Delivery 192

Frederik L. Giesel and Clemens Kratochwil

9 In Vivo Imaging and Delivery of siRNA199

Zdravka Medarova and Anna Moore

10 Imaging Cell Therapy 223

Yajie Liang and Jeff W. M. Bulte

11 Radiolabeled Liposomes as Drug Delivery Nanotheranostics
252

William T. Phillips, Ande Bao, Keitaro Sou, Shihong Li, and Beth
Goins

12 Polymeric Micelles as Imaging Agents and Drug Delivery
Systems 268

Jun Zhao and Chun Li

13 Perfluorocarbon Nanoparticles: Translating Bench
Opportunities to the Clinic 296

G. M. Lanza, P. M. Winter, S. D. Caruthers, A. H. Schmieder, and
S. A. Wickline

14 Cancer Theranostics with Hollow Gold Nanospheres 308

Wei Lu and Chun Li

15 Imaging Pulmonary Drug Delivery 333

Stephen P. Newman

16 In Vivo Imaging for Validation of Oral Dose Performance
367

Fiona J. McInnes and Howard N. E. Stevens

17 Role of Large Animal Models in Translational Studies of
Imaging and Targeted Drug Delivery 389

Rajesh K. Uthamanthil and Mei Tian

18 Imaging Transcatheter Delivery to Liver Tumors 412

Adil Al-Nahhas, Meeran Naji, and Imene Zerizer

19 Direct Visualization of Therapeutic Radionuclide Distribution
Using Nuclear Medicine Imaging: I-131 in Metastatic Thyroid
Carcinoma 426

Ho Young Lee, June-Key Chung, So Won Oh, Jong Jin Lee, Keon Wook
Kang, Do Joon Park, Bo Youn Cho, and Myung Chul Lee

20 Imaging Drug Delivery to the CNS Using Translational Positron
Emission Tomography Studies 432

Chi-Ming Lee, Katarina Varnäs, and Lars Farde

Index 449