Ecogenetics

One Significance for Public Health and Research.- 1 Report on a WHO consultation.- Two Perspectives of Genetic Predisposition.- 2 Genetic predisposition to occupationally-related diseases: current status and future directions.- 3 Genetic predisposition to environmental toxic agents: detection by distribution of ecogenetic markers.- 4 Genetic predisposition to common diseases.- Three Experimental Evidence.- 5 Evidence in laboratory animal studies of genetic predisposition to effects of toxic chemicals.- 6 Animal models for studies of genetic predisposition to adverse effects of chemical exposure.- 7 Sex-related differences in genetic susceptibility to toxic chemicals.- Four Pharmacogenetic Evidence.- 8 Lessons from pharmocogenetics.- 9 Human variability in alcohol and aldehyde metabolism: vulnerability to toxic effects.- 10 Detection of unsuspected non-fava-bean-sensitive G-6-PD deficiency in semiconductor fabrication workers in Israel.- Five Toxicogenetic Evidence.- 11 Prevalence of important polymorphisms in Poland.- 12 Phenotypes of human serum esterases reacting with organophosphates, carbamates and other esters.- 13 Predisposition in exposure to carbon disulfide.- 14 Genetic susceptibility to DNA-methylating agents.- 15 Interindividual variation in the level of DNA and protein adducts in humans.- Six Ethical and Regulatory Aspects.- 16 Ethical aspects of genetic predisposition to disease.- 17 Health policy, ethics and human values.- 18 Significance of hypersusceptibility for risk assessment.- 19 Examples of regulatory practices to protect hypersusceptible groups of workers.- Appendix: List of Participants.

Written and edited by an international team of experts, Ecogenetics is a vital reference source...Biomedicine and Pharmacotherapy; The book provides a wealth of data which contain interesting and important information to both the toxicologist and molecular biologist - Chemistry and Industry; ...this is a useful and comprehensive volume...for students or those with broad interests, this volume presents an ideal lead into the diverse areas of ecogenetics... - Animals of Human Biology; For those generally unfamiliar with this field, this is a useful and comprehensive volume - Annals of Human Biology