Pharmacogenomics of Human Drug Transporters (eBook)

TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC). RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation. JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.

PREFACE vii

CONTRIBUTORS ix

CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS
1

Marianne K. DeGorter and Richard B. Kim

CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13

Liangfu Chen and Joseph W. Polli

CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF
DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39

Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei
Huang

CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT
73

Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini

CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109

Toshihisa Ishikawa and Yoshihide Hayashizaki

CHAPTER 6 OATP1A2, OAT1, AND OAT3 125

Rommel G. Tirona

CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141

J¨org K¨onig and Martin F. Fromm

CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171

Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and
Kathleen M. Giacomini

CHAPTER 9 MATE (SLC47) FAMILY 209

Atsushi Yonezawa and Ken-ichi Inui

CHAPTER 10 PEPT (SLC15A) FAMILY 223

Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato

CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY
243

M´yriam Molina-Arcas and Marc¸al
Pastor-Anglada

CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271

Ingolf Cascorbi

CHAPTER 13 BSEP (ABCB11) 295

Bruno Stieger and Gerd A. Kullak-Ublick

CHAPTER 14 BCRP (ABCG2) 311

Agnes Basseville, Susan E. Bates, William D. Figg and Alex
Sparreboom

CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345

Anne T. Nies

CHAPTER 16 MRP4 (ABCC4) 365

Satish B. Cheepala, Mugdha Sukthankar and John D.
Schuetz

CHAPTER 17 MRP8 (ABCC11) 387

Yu Toyoda and Toshihisa Ishikawa

CHAPTER 18 FUTURE PERSPECTIVES 401

Toshihisa Ishikawa and Joseph Ware

INDEX 417