Pharmacogenomics of Human Drug Transporters (eBook)
440 Seiten
John Wiley & Sons (Verlag)
978-1-118-35320-2 (ISBN)
therapies
With this book as their guide, readers will discover how to
apply our current understanding of the pharmacogenomics of drug
transporters to advance their own drug discovery and development
efforts. In particular, the book explains how new findings in the
field now enable researchers to more accurately predict drug
interactions and adverse drug reactions. Moreover, it sets the
foundation for the development of drug therapies that are tailored
to an individual patient's genetics.
Pharmacogenomics of Human Drug Transporters serves as a
comprehensive guide to how transporters regulate the absorption,
distribution, and elimination of drugs in the body as well as how
an individual's genome affects those processes. The book's eighteen
chapters have been authored by a team of leading pioneers in the
field. Based on their own laboratory and clinical experience as
well as a thorough review of the literature, these authors explore
all facets of drug transporter pharmacogenomics, including:
* Individual drug transporters and transporter families and their
clinical significance
* Principles of altered drug transport in drug-drug
interactions, pharmacotherapy, and personalized medicine
* Emerging new technologies for rapid detection of genetic
polymorphisms
* Clinical aspects of genetic polymorphisms in major drug
transporter genes
* Future research directions of drug transporter pharmacogenomics
and the prospect of individualized medicine
Pharmacogenomics of Human Drug Transporters opens the
door to new drug discovery and development breakthroughs leading to
safer and more effective customized drug therapies.The book is
recommended for pharmaceutical scientists, biochemists,
pharmacologists, clinicians, and genetics and genomics
researchers.
TOSHIHISA ISHIKAWA, PhD, is Senior Scientist at RIKEN Yokohama Institute and Professor of Biochemistry, Molecular Biology, and Pharmacogenomics at Yokohama City University's Graduate School of Medicine. Previously, Dr. Ishikawa was the Director of the Department of Research Technology Development at Pfizer, Japan. A recipient of the Achievement Award from the International Life Sciences Institute (ILSI), Dr. Ishikawa is also the cofounder of the International Transporter Consortium (ITC). RICHARD B. KIM, MD, FRCPC, is Professor and Chair of the Division of Clinical Pharmacology and Associate Chair for Research in the Department of Medicine at the University of Western Ontario. He is a Fellow of the American Association of Pharmaceutical Scientists and an elected member of the American Society for Clinical Investigation. JÖRG KÖNIG, PhD, is Professor and Head of the Molecular Biology Laboratories in the Department of Clinical Pharmacology at the Friedrich-Alexander Universität Erlangen-Nürnberg.
PREFACE vii
CONTRIBUTORS ix
CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS
1
Marianne K. DeGorter and Richard B. Kim
CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13
Liangfu Chen and Joseph W. Polli
CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF
DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39
Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei
Huang
CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT
73
Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini
CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109
Toshihisa Ishikawa and Yoshihide Hayashizaki
CHAPTER 6 OATP1A2, OAT1, AND OAT3 125
Rommel G. Tirona
CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141
J¨org K¨onig and Martin F. Fromm
CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171
Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and
Kathleen M. Giacomini
CHAPTER 9 MATE (SLC47) FAMILY 209
Atsushi Yonezawa and Ken-ichi Inui
CHAPTER 10 PEPT (SLC15A) FAMILY 223
Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato
CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY
243
M´yriam Molina-Arcas and Marc¸al
Pastor-Anglada
CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271
Ingolf Cascorbi
CHAPTER 13 BSEP (ABCB11) 295
Bruno Stieger and Gerd A. Kullak-Ublick
CHAPTER 14 BCRP (ABCG2) 311
Agnes Basseville, Susan E. Bates, William D. Figg and Alex
Sparreboom
CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345
Anne T. Nies
CHAPTER 16 MRP4 (ABCC4) 365
Satish B. Cheepala, Mugdha Sukthankar and John D.
Schuetz
CHAPTER 17 MRP8 (ABCC11) 387
Yu Toyoda and Toshihisa Ishikawa
CHAPTER 18 FUTURE PERSPECTIVES 401
Toshihisa Ishikawa and Joseph Ware
INDEX 417
| Erscheint lt. Verlag | 12.3.2013 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
| Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik | |
| Technik ► Umwelttechnik / Biotechnologie | |
| Schlagworte | Biowissenschaften • Chemie • Chemistry • Drug Discovery & Development • Life Sciences • Medical Science • Medizin • molecular genetics • Molekulargenetik • Pharmacology & Pharmaceutical Medicine • Pharmakologie • Pharmakologie u. Pharmazeutische Medizin • Wirkstoffforschung • Wirkstoffforschung u. -entwicklung |
| ISBN-10 | 1-118-35320-X / 111835320X |
| ISBN-13 | 978-1-118-35320-2 / 9781118353202 |
| Haben Sie eine Frage zum Produkt? |
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