Preparative Enantioselective Chromatography (eBook)

Dr Geoffrey B Cox (Editor)VP & General Manager, Separation Solutions

Contributors.

Preface.

1. Chiral Chromatography in Support of Pharmaceutical Process
Research (Christopher J. Welch).

2. Introduction to Preparative Chromatography (Geoffrey B.
Cox).

3. Chiral Stationary Phases for Preparative Enantioselective
Chromatography (Eric Francotte).

4. Method Development for Preparative Enantioselective
Chromatography (Christina Suteu).

5. Scaling-Up of Preparative Chromatographic Enantiomer
Separations (Jules Dingenen).

6. Steady-State Recycling and Its use in Chiral Separations
(Charles M. Grill and Laurence M. Miller).

7. Simulated Moving Bed and Related Techniques (Luís S.
Pais, Vera G. Mata and Alírio E. Rodrigues).

8. Preparative-Scale Supercritical Fluid Chromatography (Manon
S. Villeneuve and Luke A. Miller).

9. Equipment for Preparative and Large Size Enantioselective
Chromatography (Henri Colin, Olivier Ludemann-Hombourger and
Félicie Denet).

10. Case Study in Production-Scale Multicolumn Continuous
Chromatography (Michel Hamende).

11. Contract Manufacturing and Outsourcing Considerations
(Olivier Dapremont).

Appendix: Advanced Concepts.

Index.

"With such a good coverage of the topics and a generous collection
of references, the book is a pleasure to read and refer to. The
book has struck almost exactly the right note in attractiveness of
purpose and method of presentation. The book has a distinctly
readable quality.

Both the editor and the authors are to be commended for sharing
their insights and experience in such an easily accessed
volume.

The entire volume is lavishly illustrated with tables, graphs and
drawings, the design and execution and placement of which are as
perfect as the text material they illustrate."

Current Engineering Practice

'The book is a delight to read.'

'Cox's book provides chemists and chemical engineers with
valuable hints and advises. The authors are, in part, experienced
practitioners in the industry and academics at the forefront of
this field...at every stage, material is logically presented and
easy to access.'

'In summary, this is an excellent compiled book with
well-produced text'

Gregor Mann, Organic Process Research and Development,
September 2005

"This book represents a valuable source of information on the
multifaceted challenges one may encounter when performing
preparative chromatographic enantiomer seperations, and large-scale
chromatography in general ... [this] account will be warmly
welcomed by clientele from both industry and academia, as it offers
insightful and enjoyable reading, even to the expert."

Analytical and Bioanalytical Chemistry