Practical Synthetic Organic Chemistry (eBook)

Reactions, Principles, and Techniques

St phane Caron (Herausgeber)

eBook Download: PDF
2011 | 1. Auflage
898 Seiten
Wiley (Verlag)
978-1-118-09357-3 (ISBN)

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A hands-on guide to assist in the planning and execution of synthetic reactions in the laboratory Despite the maturity of organic chemistry, it can still be very challenging to identify optimal methods for synthetic transformations that perform as well in real-world manufacturing processes as they do in the laboratory. This detailed and accessible guide attempts to address this vexing issue and deliver proven methodologies practicing synthetic chemists will find valuable for identifying reaction conditions that work reliably over the broadest possible range of substrates. Practical Synthetic Organic Chemistry: Provides a practical guide to strategically planning and executing chemical syntheses for the bench chemist in industry Discusses information that is not common knowledge beyond the boundaries of process chemistry groups, such as the synthetic routes of selected contemporary pharmaceutical drugs and practical solvents, as well as green chemistry concepts Highlights key reactions, including substitutions, additions, eliminations, rearrangements, oxidations, and reductions Addresses basic principles, mechanisms, advantages and disadvantages of the methodology, and techniques for achieving laboratory success Incorporating such an extraordinary wealth of information on organic chemistry and its related fields into one complete volume distinguishes Practical Synthetic Organic Chemistry as an incomparable desktop reference for professionals and an invaluable study aid for students.

Stephane Caron is a manager in Chemical Research &Development at Pfizer.

Preface.

Chapter 1: Aliphatic Nucleophilic Substitution (Jade D.Nelson).

Chapter 2: Addition to Carbon-Heteroatom Multiple Bonds(Rajappa Vaidyanathan and Carrie Brockway Wager).

Chapter 3: Addition to Carbon-Carbon Multiple Bonds(John A. Ragan).

Chapter 4: Nucleophilic Aromatic Substitution (StéphaneCaron and Arun Ghosh).

Chapter 5: Electrophilic Aromatic Substitution (StéphaneCaron).

Chapter 6: Selected Metal-mediated cross-coupling reactions(Stéphane Caron, Arun Ghosh, Sally Gut Ruggeri, Nathan D.Ide, Jade D. Nelson, and John A. Ragan).

Chapter 7: Rearrangements (David H. B. Ripin).

Chapter 8: Eliminations (Sally Gut Ruggeri).

Chapter 9: Reductions (Sally Gut Ruggeri, StéphaneCaron, Pascal Dubé, Nathan D. Ide, Kristin E. Price, John A.Ragan, and Shu Yu).

Chapter 10: Oxidations (David H. Brown Ripin).

Chapter 11: Selected Free Radical Reactions (Nathan D.Ide).

Chapter 12: Synthesis of "Nucleophilic" Organometallic Reagents(David H. Brown Ripin).

Chapter 13: Synthesis of Common Aromatic Heterocycles(Stéphane Caron).

Chapter 14: Access to Chirality (Robert W. Dugger).

Chapter 15: Synthetic Route Development of Selected ContemporaryPharmaceutical Drugs (Stéphane Caron).

Chapter 16: Green Chemistry (Juan C. Colberg).

Chapter 17: Naming Carbocycles and Heterocycles (Heather N.Frost and David H. B. Ripin).

Chapter 18: pKa (David H. Brown Ripin).

Chapter 19: General Solvent Properties (StéphaneCaron).

Chapter 20: Practical Chemistry Concepts Tips for the PracticingChemist or Things They Don't Teach You in School (Sally GutRuggeri).

"The last sentence by editor Caron is an appropriateconclusion: "Building each chapter ... served as anexcellent chemistry refresher course for the authors, and welearned a lot of new chemistry in the process." Chemistseverywhere will applaud their effortsand." (Angewandte Chemie, 2012)

"The book is extremely good value, partly because it is notavailable in hardback and whilst this may please budget-holdersinitially, it also is another good reason for looking forward to asecond edition. . . Overall, apart from one or two very minorcomplaints, this book is highly recommended, in fact it should be amust for all practising synthetic organic chemists." (OrganicProcess Research & Development Journal, 2011)

"...an emphasis on practicality, scalability and efficiency... Iwould imagine this will be a popular teaching text in universitiesbut it should also be read by process chemists for an insight intogood synthetic organic chemistry and route design. It looksexcellent value for money." (Scientific Update, 2011)

Erscheint lt. Verlag 5.7.2011
Sprache englisch
Themenwelt Naturwissenschaften Chemie Organische Chemie
Technik
Schlagworte Chemie • Chemistry • Industrial Chemistry • Organic Chemistry • Organische Chemie • Organische Synthese • Pharmaceutical & Medicinal Chemistry • Pharmazeutische u. Medizinische Chemie • Technische u. Industrielle Chemie
ISBN-10 1-118-09357-7 / 1118093577
ISBN-13 978-1-118-09357-3 / 9781118093573
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