Randomization in Clinical Trials (eBook)

WILLIAM F. ROSENBERGER is an associate professor (with tenure) ofmathematics and statistics at The University of Maryland, BaltimoreCounty. He is also an adjunct associate professor of epidemiologyand preventive medicine at the University of Maryland School ofMedicine. He serves as a biostatistical consultant on severalclinical trials data and safety monitoring boards for the NIH, VA,and industry. He received his PhD in mathematical statistics fromThe George Washington University. JOHN M. LACHIN III is presently Professor of Biostatistics andEpidemiology, and of Statistics, at The George WashingtonUniversity. He holds a ScD in biostatistics from the University ofPittsburgh. He also serves as Director of the Graduate Program inBiostatistics and as Director of the Coordinating Center for twonationwide studies in diabetes.

Preface.

Randomization and the Clinical Trial.

Issues in the Design of Clinical Trials.

Randomization for Balancing Treatment Assignments.

Balancing on Known Covariates.

The Effects of Unobserved Covariates.

Selection Bias.

Randomization as a Basis for Inference.

Inference for Stratified, Blocked, and Covariate-AdjustedAnalyses.

Randomization in Practice.

Response-Adaptive Randomization.

Inference for Response-Adaptive Rondomization.

Response-Adaptive Randomization in Practice.

Some Useful results in Large Sample Theory.

Large Sample Inference for Complete and RestrictedRandomization.

Large sample Inference for Response-Adaptive Randomization.

Author Index.

Subject Index.

"...excellent for learning on how to use randomizationideas..." (Journal of Statistical Computation &Simulation, May 2004)

"This book is one of the first to devote a substantial part ofits content to the theory and practice of the techniques ofresponse-adaptive design in the context of randomized clinicaltrials." (Apria Healthcare)

"...should be very useful in graduate courses...a valuablereference work..." (Short Book Reviews, 2004)

"All medical statisticians involved in clinical trials shouldread this book...." (Controlled Clinical Trials)

"..combines the applied aspects of randomization inclinical trials with a probabilistic treatment of properties ofrandomization..." (Quarterly of Applied Mathematics,Vol. LXI, No. 2, June 2003)