Chiral Separation Methods for Pharmaceutical and Biotechnological Products (eBook)

SATINDER (SUT) AHUJA is a recognized expert in the field of chromatography and separations who has published numerous papers and more than a dozen books, including three on chiral separations. As president of Ahuja Consulting, he has advised major pharmaceutical companies in the United States, Europe, and India. He has also taught short courses for ACS and AAPS on chiral separations by chromatography. Recently, Dr. Ahuja chaired a symposium on Chiral Separations at the American Chemical Society meeting in Boston.

Contributors.

Preface.

1 Overview of Chiral Separations (Satinder
Ahuja).

2 Regulatory & Development Considerations of Chiral
Compounds (Robert L. Zeid).

3 Basic Considerations in Method Development for Chiral
Compounds (Satinder Ahuja).

4 Separations of Chiral Compounds on Polysaccharide
Columns (Clinton W. Amoss and Norbert M. Maier).

5 Chiral Separations by Various Techniques (Jian G.
Ning).

6 Chiral Discrimination Study for Polysaccharide Based Chiral
Stationary Phase (Yun K. Ye).

7 Comparison of Chiral Chromatographic Columns for
Pharmaceuticals (Gregory K. Webster).

8 Chiral Separation Screens for Pharmaceutical Analysis and
Purification in an Industrial Laboratory Environment (Robert
DePianta, Kenneth Douville, Beverly Nickerson, and Ricardo E.
Borjas).

9 The Separation of Enantiomers by Gas Chromatography on
Chiral Stationary Phases (Volker Schurig).

10 Separations of Chiral Compounds by SFC (Ziqiang
Wang).

11 Chiral Separations by Capillary Electrophoresis
(Debby Mangelings and Yvan Vander Heyden).

12 High-Throughput Screening and Method-Development
Strategies to Separate Chiral Drug Compounds in HPLC, SFC, and
CE (Hasret Ates, Debby Mangelings and Yvan Vander
Heyden).

13 Use of Enantioselective Synthesis and Preparative Chiral
Chromatography to Access a Challenging Enantiopure Pharmaceutical
Candidate from a Mixture of Four Stereoisomers (Christopher
J. Welch, Derek H. Henderson, William R. Leonard, Mirlinda Biba,
Mike Zacuto, Fred Fleitz, Amude Kassim, Cheng-yi Chen, and Peter
Sajonz).

14 A Look into the Future: Chiral Analysis Using Chemical
Sensor Technology (Gregory K. Webster and William J.
Buttner).

15 Chirality of Biomolecules and Biotechnology Products
(Satinder Ahuja).

Index.

"All chapters are thorough and well written by leading
experts in the particular fields. The book provides researchers and
students in the field of pharmaceutical sciences with a thorough
understanding of chiral separations and offers a convenient route
to selecting best chiral separation method." (Anal
Bioanal Chem, 2011)

"This is an essential text for analytical and separations
scientists in the biotechnological, pharmaceutical, agricultural,
and food industries, as well as students." (Laboratory Journal, 22
November 2010)