Flexible Viruses (eBook)

VLADIMIR N. UVERSKY is an Associate Professor at the Department of Molecular Medicine at the University of South Florida (USF). He obtained his academic degrees from Moscow Institute of Physics and Technology (PhD in 1991) and from the Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences (DSc in 1998). He spent his early career working mostly on protein folding at the Institute of Protein Research and Institute for Biological Instrumentation, Russia. In 1998, he moved to the University of California Santa Cruz where for six years he was studying protein folding, misfolding, protein conformation diseases, and protein intrinsic disorder phenomenon. In 2004, he was invited to join the Indiana University School of Medicine as a Senior Research Professor to work on intrinsically disordered proteins. Since 2010, Professor Uversky is with USF, where he continues to study intrinsically disordered proteins and protein folding and misfolding processes. He has authored over 400 scientific publications and edited several books and book series on protein structure, function, folding and misfolding. SONIA LONGHI is a Director of Research at the Center for the National Scientific Research (CNRS). She obtained her academic degree (PhD) from the University of Milan in 1993. She then went to the Architecture and Function of Biological Macromolecules laboratory (AFMB, UMR 6098, CNRS and Aix-Marseille University) where she did postdoctoral work on protein crystallography. Since 2006, she has been heading the "Structural Disorder and Molecular Recognition" group within the AFMB laboratory. She has authored more than 70 scientific publications and edited a book on measles virus nucleoprotein and coedited, with Prof. Vladimir Uversky, a book entitled Instrumental Analysis of Intrinsically Disordered Proteins (Wiley).

Preface.

1. Do viral proteins possess unique features? (Vladimir
Uversky).

2. Functional role of structural disorder in capsid proteins
(Lars Liljas).

3. Structural disorder within the nucleoproteins and
phosphoproteins of measles, Nipah and Hendra viruses (Johnny
Habchi and Sonia Longhi).

4. Structural disorder within the Sendai virus nucleoprotein and
phosphoprotein (Rob Ruigrok and Martin Blackledge).

5. Structural disorder in Rhabdoviridae phosphoproteins (Marc
Jamin).

6. Structural disorder in matrix proteins from HiV-related
viruses (Vladimir Uversky and Keith Dunker).

7. Structural disorder in proteins from influenza virus
(Vladmir Uversky and Keith Dunker).

8. Structural disorder in the HIV-1 Vif protein and
oilgomerization-dependent gain of structure (Assaf
Friedler).

9. Order from Disorder: Structure, Function and Dynamics of the
HIV-1 Transactivator of Transcription (Joe D.
O'Neil).

10. Intrinsically disordered protein domains of the non
structural proteins of Sesbania mosaic virus and their functional
role (Handanahal S. Savithri).

11. Intrinsic disorder in genome-linked viral proteins VPgs of
potyviruses (Jadwiga Chroboczek, Eugénie Hébrard,
Kristiina Mäkinen, Thierry Michon and Kimmo
Rantalainen).

12. Intrinsic disorder in HPV 16 E7 protein (Gonzalo de
Prat-Gay).

13. The Semiliki forest virus serine protease is disordered and
yet displays catalytic activity (Manuel Morillas).

14. Intrinsic disorder in the core proteins of
Flaviviridae (Jean-Luc Darlix).

15. Domains 2 and 3 of non-structural protein 5A (NS5A) of
hepatitis C virus is natively unfolded (Ho Sup Yoon).

16. Intrinsic disorder within phage lambda N protein and
interaction with the E. coli NusA protein (Kristian
Schweimer).

17. The N-terminal extension region of Hordeivirus
movement TGB1 protein consists of two domains with different
content of disordered structure (V.V. Makarov, M.E. Tailansky,
E.N. Dobrov, N.O. Kalinina).