Organelle-Specific Pharmaceutical Nanotechnology (eBook)

Volkmar Weissig, ScD, PhD, is Associate Professor of Pharmacology at Midwestern University in Glendale, Arizona. He has been actively pioneering mitochondrial pharmaceutics for the last decade. The holder of sixteen patents and author of more than eighty research papers, review articles, and book chapters, Dr. Weissig serves as Associate Editor of the Journal of Liposome Research and is the member of several other editorial boards. He is an active member of the International Liposome Society, the Mitochondria Research Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science. Gerard G.M. D'Souza, PhD, is Assistant Professor of Pharmaceutics at Massachusetts College of Pharmacy and Health Sciences in Boston. He has coauthored more than twenty peer-reviewed publications in the fields of pharmaceutical nanotechnology and mitochondrial pharmaceutics. Dr. D'Souza is a member of the editorial board for the Journal Drug Delivery and serves as a peer reviewer for several journals in the field of drug delivery.

Preface.

Contributors.

1. An Introduction to Subcellular Nanomedicine: Current Trendsand Future Developments (Gerard G. M. D'Souza and VolkmarWeissig).

2. Delivery of Nanonsensors to Measure the IntracellularEnvironment (Paul G. Coupland and Jonathan W. Aylott).

3. Cytoplasmic Diffi usion of Dendrimers and Dendriplexes(Alexander T. Florence and Pakatip Ruenraroengsak).

4. Endocytosis and Intracellular Trafficking of QuantumDot-Ligand Bioconjugates (Tore-Geir Iversen, Nadine Frerker, andKirsten Sandvig).

5. Synthesis of Metal Nanoparticle-Based IntracellularBiosensors and Therapeutic Agents (Neil Bricklebank).

6. Subcellular Fate of Nanodelivery Systems (DusicaMaysinger, Sebastien Boridy, and Eliza Hutter).

7. Intracellular Fate of Plasmid DNA Polyplexes (Kevin Maierand Ernst Wagner).

8. Intracellular Trafficking of Membrane Receptor-MediatedUptake of Carbon Nanotubes (Bin Kang and Yaodong Dai).

9. Real-Time Particle Tracking for Studying IntracellularTransport of Nanotherapeutics (Clive Chen and JunghaeSuh).

10. Tracking Intracellular Polymer Localization Via FluorescenceMicroscopy (Simon C. W. Richardson).

11. Can QSAR Models Describing Small-Molecule Xenobiotics GiveUseful Tips for Predicting Uptake and Localization of Nanoparticlesin Living Cells? And If Not, Why Not? (Richard W.Horobin).

12. Self-Unpacking Gene Delivery Scaffolds (Millicent O.Sullivan).

13. Cellular Trafficking of Dendrimers (Yunus Emre Kurtogluand Rangaramanujam M. Kannan).

14. Endolysosomolytically Active pH-Sensitive PolymericNanotechnology (Han Chang Kang and You Han Bae).

15. Uptake and Intracellular Dynamics of Proteins Internalizedby Cell-Penetrating Peptides (Arwyn T. Jones).

16. Cargo Transport by Teams of Molecular Motors: BasicMechanisms for Intracellular Drug Delivery (Melanie J. I.Müller, Florian Berger, Stegan Klumpp, and ReinhardLipowsky).

17. The Potential of Photochemical Internalization (PCI) for theCytosolic Delivery of Nanomedicines (Kristian Berg, AnetteWeyergang, Anders Høgset, and Pål KristianSelbo).

18. Peptide-Based Nanocarriers for Intracellular Delivery ofBiologically Active Proteins (Seong Loong Lo and ShuWang).

19. Organelle-Specific Pharmaceutical Nanotechnology: ActiveCellular Transport of Submicro- and Nanoscale Particles (GalyaOrr).

20. Subcellular Targeting of Virus-Envelope-Coated Nanoparticles(Jia Wang, Mohammad F. Saeed, Andrey A. Kolokoltsov, and RobertA. Davey).

21. Mitochondria-Targeted Pharmaceutical Nanocarriers(Volkmar Weissig and Gerard G.M. D'Souza).

22. Cell-Penetrating Peptides for Cytosolic Delivery ofBiomacromolecules (Camilla Foged, Xiaona Jing, and Hanne MoerckNielsen).

23. Therapeutic Nano-object Delivery to Subdomains of CardiacMyocytes (Valeriy Lukyanenko).

24. Design Parameters Modulating Intracellular Drug Delivery:Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Useof Auxiliary Pharmacological Agents (Silvia Muro and Vladimir R.Muzykantov).

25. Uptake Pathways Dependent Intracellular Trafficking of DNACarrying Nanodelivery Systems (Ikramy A. Khalil, Yuma Yamada,Hidetaka Akita, and Hideyoshi Harashima).

26. Cellular Interactions of Plasmon-Resonant Gold Nanorods(Qingshan Wei and Alexander Wei).

27. Quantum Dot Labeling for Assessment of IntracellularTrafficking of Therapeutically Active Molecules (Diane J.Burgess and Mamta Kapoor).

Index.