Microbial Proteomics (eBook)

Functional Biology of Whole Organisms
eBook Download: PDF
2006 | 1. Auflage
530 Seiten
John Wiley & Sons (Verlag)
978-0-471-97315-7 (ISBN)

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Discover important lessons learned about whole organism biology
via microbial proteomics

This text provides an exhaustive analysis and presentation of
current research in the field of microbial proteomics, with an
emphasis on new developments and applications and future directions
in research. The editors and authors show how and why the relative
simplicity of microbes has made them attractive targets for
extensive experimental manipulation in a quest for both improved
disease prevention and treatment and an improved understanding of
whole organism functional biology. In particular, the text
demonstrates how microbial proteomic analyses can aid in drug
discovery, including identification of new targets, novel
diagnostic markers, and lead optimization.

Each chapter is written by one or more leading experts in the
field and carefully edited to ensure a consistent and thorough
approach throughout. Methods, technologies, and tools associated
with the most promising approaches are stressed. Key topics covered
include:

* Microbial pathogenesis at the proteome level

* Whole cell modeling

* Structural proteomics and computational analysis

* Biomolecular interactions

* Physiological proteomics

* Metabolic reconstruction using proteomics data

While presenting the practical utility of proteomics data, the
text is also clear on the field's current limitations, pointing to
areas where further investigation is needed.

Offering a state-of-the-art perspective from internationally
recognized experts, this text is ideally suited for researchers and
students across the gamut of genomic sciences, including
biochemistry, microbiology, molecular biology, genetics, biomedical
and pharmaceutical sciences, biotechnology, and veterinary
science.

IAN HUMPHERY-SMITH, PHD, is the Founding Chair of the Department of Pharmaceutical Proteomics at Utrecht University. Dr. Humphery-Smith has served as director of the Centre for Proteome Research and Gene-Product Mapping and served as managing director and chief scientific officer of Glaucus Proteomics BV. MICHAEL HECKER, PHD, is Professor of Microbiology and Head of the Institute for Microbiology at Ernst-Moritz-Arndt-University of Greifswald in Germany. Dr. Hecker is currently Vice Chair of the International Union of Microbiological Societies (IUMS).

PREFACE.

ACKNOWLEDGMENTS.

CONTRIBUTORS.

PART I: GENERAL PROTEOMICS OF MICROORGANISMS/MODELORGANISMS.

1. Holistic Biology of Microorganisms: Genomics,Transcriptomics, and Proteomics (Valerie Wasinger).

2. Strategies for Measuring Dynamics: The Temporal Component ofProteomics (Robert J. Beynon and Julie M. Pratt).

3. Quest for Complete Proteome Coverage (C. DavidO'Connor, Ian N. Clarke, and Paul Skipp).

4. Proteome of Mycoplasma pneumoniae (Richard Herrmann andThomas Ruppert).

5. Proteomics of Archaea (Ricardo Cavicchioli, AmberGoodchild, and Mark Raftery).

PART II: PROTEOMICS AND CELL PHYSIOLOGY.

6. Elucidation of Mechanisms of Acid Stress in Listeriamonocytogenes by Proteomic Analysis (Luu Phan-Thanh and LotharJänsch).

7. Oxidation of Bacterial Proteome in Response to Starvation(Thomas Nyström).

8. Tale of Two Metal Reducers: Comparative Proteome Analysis ofGeobacter sulferreducens PCA and Shewanella oneidensis MR-1(Carol S. Giometti).

9. AMT Tag Approach to Proteomic Characterization of Deinococcusradiodurans and Shewanella oneidensis (Mary S. Lipton, MargaretF. Romine, Matthew E. Monroe, Dwayne A. Elias, Ljiljana Pasa-Tolic,Gordon A. Anderson, David J. Anderson, Jim Fredrickson, Kim K.Hixson, Christophe Masselon, Heather Mottaz, Nikola Tolic, andRichard D. Smith).

PART III: PHYSIOLOGICAL PROTEOMICS OF INDUSTRIALBACTERIA.

10. Proteomics of Corynebacterium glutamicum: EssentialIndustrial Bacterium (Andreas Burkovski).

11. Proteomics of Lactococcus lactis: Phenotypes for a DomesticBacterium (Mogens Kilstrup).

12. Proteomic Survey through Secretome of Bacillus subtilis(Haike Antelmann, Jan Maarten van Dijl, Sierd Bron, and MichaelHecker).

PART IV: PROTEOMICS OF PATHOGENIC MICROORGANISMS.

13. Analyzing Bacterial Pathogenesis at Level of Proteome(Phillip Cash).

14. Unraveling Edwardsiella tarda Pathogenesis Using theProteomics Approach (P. S. Srinivasa Rao, Yuen Peng Tan, JunZheng, and Ka Yin Leung).

15. Structural Proteomics and Computational Analysis of a DeadlyPathogen: Combating Mycobacterium tuberculosis from Multiple Fronts(Michael Strong and Celia W. Goulding).

16. Proteomic Studies of Plant-Pathogenic Oomycetes and Fungi(Catherine R. Bruce, Pieter van West, and Laura J.Grenville-Briggs).

17. Candida albicans Biology and Pathogenicity: Insights fromProteomics (Aida Pitarch, Ce´sar Nombela, and ConchaGil).

18. Contributions of Proteomics to Diagnosis, Treatment, andPrevention of Candidiasis (Aida Pitarch, Ce´sar Nombela,and Concha Gil).

19. Identification of Protein Candidates for DevelopingBacterial Ghost Vaccines against Brucella (Vito G. Delvecchio,Tim Alefantis, Rodolfo A. Ugalde, Diego Comerci, Maria InesMarchesini, Akbar Khan, Werner Lubitz, and Cesar V. Mujer).

20. Genomics and Proteomics in Reverse Vaccines (GuidoGrandi).

PART V: PROTEOME DATABASES, BIOINFORMATICS, AND BIOCHEMICALMODELING.

21. Databases and Resources for in silico Proteome Analysis(Manuela Pruess, Paul Kersey, Tamara Kulikova, and RolfApweiler).

22. Interspecies and Intraspecies Comparison of MicrobialProteins: Learning about Gene Ancestry, Protein Function, andSpecies Life Style (Bernard Labedan and OlivierLespinet).

23. Cellular Kinetic Modeling of the Microbial Metabolism(Igor I. Goryanin, Galina V. Lebedeva, Ekaterina A.Mogilevskaya, Eugeniy A. Metelkin, and Oleg V. Demin).

INDEX.

"The authors have provided a thorough overview of what is still a relatively new field of study." (CHOICE, January 2007)

Erscheint lt. Verlag 11.10.2006
Reihe/Serie Methods of Biochemical Analysis
Methods of Biochemical Analysis
Sprache englisch
Themenwelt Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Technik
Schlagworte Biologie • Biotechnologie • Biotechnologie i. d. Chemie • Biotechnology • Biowissenschaften • Chemie • Chemistry • Genomforschung u. Proteomik • Genomics & Proteomics • Life Sciences • Microbiology & Virology • Mikrobiologie u. Virologie • Proteomics
ISBN-10 0-471-97315-7 / 0471973157
ISBN-13 978-0-471-97315-7 / 9780471973157
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