Metal Complex - DNA Interactions (eBook)

Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.

A Basic Structural and Kinetic Aspects

1. Sequence-Selective Binding of Transition Metal Complexes to
DNA

2. Thermodynamic Models of Metal Ion -DNA.Interactions

3. Metal Ion Coordination in G-quadruplexes

4. Supramolecular Chemistry of Metal-Nucleobase Complexes

B Medical Applications

5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand
Interactions,

nucleotides and DNA

6. Role of DNA Repair in Antitumor Effects of Platinum Drugs

7. Telomeres and Telomerase: Potential Targets for Platinum
Complexes

8. Toward Photodynamic Therapy of Cancer with Platinum Group
Metal Polyazine Complexes

9. Platinated Oligonucleotides: Synthesis and Applications for
the Control of Gene

Expression

10. New Titanium and Ruthenium Anticancer Drugs and their
Interaction with DNA

C DNA-Recognition - Nucleases and Sensors

11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA
Recognition

12. DNA Recognition and Binding by Peptide-Metal Complex
conjugate

13. Artificial Restriction Agents - Hydrolytic Agents for DNA
Cleavage

14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA
Interactions and

Metal Sensing Applications

15. Two-metal Ion Dependent Catalysis in Nucleic Acid
Enzymes

D Toxicological aspects

16. Mercury- DNA Interactions. Structural Studies on
Mercury¯II -Mediated T-T Base-Pair with NMR
Spectroscopy

17. Chromium-Induced DNA Damage and Repair

18. Arsenic and nickel: Mechanisms Affecting DNA Integrity

"An impressive overview of the great diversity of current
research." (Angewandte Chemie International Edition,
February 2010)



"An essential part of the library for laboratories involved in
bioinorganic and medicinal inorganic chemistry." (Chemistry
World, September 2009)