Metal Complex - DNA Interactions (eBook)
544 Seiten
John Wiley & Sons (Verlag)
978-1-4051-9410-5 (ISBN)
critically important components of nucleic acid chemistry, both in
regulation of gene expression and as promising therapeutic agents.
Understanding how metal complexes interact with DNA has become an
active research area at the interface between chemistry, molecular
biology and medicine.
Metal Complex - DNA Interactions provides a comprehensive
overview of this increasingly diverse field, presenting recent
developments and the latest research with particular emphasis on
metal-based drugs and metal ion toxicity. The text is divided into
four parts:
* Basic Structural and Kinetic Aspects: includes chapters
on sequence-selective metal binding to DNA and thermodynamic
models.
* Medical Applications: focuses on anticancer platinum
drugs, including discussions on DNA repair in antitumor effects of
platinum drugs and photo-dynamic therapy.
* DNA-Recognition - Nucleases and Sensor: describes
probes for DNA recognition, artificial restriction agents,
metallo-DNAzymes for metal sensing applications and metal ion
dependent catalysis in nucleic acid enzymes.
* Toxicological Aspects: deals with structural studies of
mercury-DNA interactions, chromium-induced DNA damage and
repair, and the effect of arsenic and nickel on DNA
integrity.
This book will be a valuable resource for academic researchers
and professionals from a range of pharmaceutical and chemical
industries, particularly those involved in the development of new
and less toxic anticancer metallo-drugs, and in the field of
environmental and toxicological chemistry.
Nikolaos Hadjiliadis is Professor in the Dept of Chemistry at the University of Ioannina, Greece. Einar Sletten is Professor in the Dept of Chemistry at the University of Bergen, Norway.
A Basic Structural and Kinetic Aspects
1. Sequence-Selective Binding of Transition Metal Complexes to
DNA
2. Thermodynamic Models of Metal Ion -DNA.Interactions
3. Metal Ion Coordination in G-quadruplexes
4. Supramolecular Chemistry of Metal-Nucleobase Complexes
B Medical Applications
5. Platinum Drugs, Nucleotides, and DNA: the Role of Interligand
Interactions,
nucleotides and DNA
6. Role of DNA Repair in Antitumor Effects of Platinum Drugs
7. Telomeres and Telomerase: Potential Targets for Platinum
Complexes
8. Toward Photodynamic Therapy of Cancer with Platinum Group
Metal Polyazine Complexes
9. Platinated Oligonucleotides: Synthesis and Applications for
the Control of Gene
Expression
10. New Titanium and Ruthenium Anticancer Drugs and their
Interaction with DNA
C DNA-Recognition - Nucleases and Sensors
11. Groove-Binding Ruthenium(II) Complexes as Probes of DNA
Recognition
12. DNA Recognition and Binding by Peptide-Metal Complex
conjugate
13. Artificial Restriction Agents - Hydrolytic Agents for DNA
Cleavage
14. New Metallo-DNAzymes: Fundamental Studies of Metal-DNA
Interactions and
Metal Sensing Applications
15. Two-metal Ion Dependent Catalysis in Nucleic Acid
Enzymes
D Toxicological aspects
16. Mercury- DNA Interactions. Structural Studies on
Mercury¯II -Mediated T-T Base-Pair with NMR
Spectroscopy
17. Chromium-Induced DNA Damage and Repair
18. Arsenic and nickel: Mechanisms Affecting DNA Integrity
"An impressive overview of the great diversity of current
research." (Angewandte Chemie International Edition,
February 2010)
"An essential part of the library for laboratories involved in
bioinorganic and medicinal inorganic chemistry." (Chemistry
World, September 2009)
Erscheint lt. Verlag | 30.3.2009 |
---|---|
Sprache | englisch |
Themenwelt | Naturwissenschaften ► Biologie |
Naturwissenschaften ► Chemie ► Anorganische Chemie | |
Technik | |
Schlagworte | Anorganische Chemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Biowissenschaften • Cell & Molecular Biology • Chemie • Chemistry • DNS • Inorganic Chemistry • Life Sciences • Metallkomplexe • Zell- u. Molekularbiologie |
ISBN-10 | 1-4051-9410-3 / 1405194103 |
ISBN-13 | 978-1-4051-9410-5 / 9781405194105 |
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