Cell Motility (eBook)

From Molecules to Organisms
eBook Download: PDF
2005 | 1. Auflage
364 Seiten
John Wiley & Sons (Verlag)
978-0-470-09409-9 (ISBN)

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Recent advances in molecular and biophysical techniques,
particularly fluorescence and live cell imaging, are
revolutionizing the study of cell motility. New bioprobes not only
reveal simple intracellular localization, but also contain details
of post-translational modifications, conformational state and
protein-protein interactions. Coupling these insights with
complementary advances in genetic and biochemical methods is
enabling scientists to understand the processes involved in cell
motility - from molecular motors to cell movements in vivo in a
range of organisms and cell types.

This book features landmark essays that provide an up to date and
fascinating account of current research and concepts in cell
motility.These cover the roles of molecular motors that drive
movement and their interactions with the cytoskeleton as well as
membrane dynamics that allow cells to change shape and to
move.

Cell motility plays a key role in development - there are chapters
on the genetics of cell migration, the regulation of contact
repulsion in growth cones, and the progression from cell migration
to cell-cell adhesion. Cell motility is directional - experts
describe the molecules that regulate chemotaxis, allowing cells to
migrate along pathways specified by chemical gradients. Finally,
cell motility can be perturbed by mutation--metastasis occurs when
cells lose their normal intercellular interactions and invade other
tissue types. All these processes are regulated by signals from the
environment, including other tissues in the body, and the various
molecules that transmit and transduce these signals are
discussed.

This book is a 'must read' for cell biologists working in a variety
of fields, from development to wound healing, at all levels -
post-doctoral fellows, post-graduate students and lab technicians.
It is also stimulating reading for molecular and developmental
biologists, biophysicists and biochemists.

Anne Ridley is the editor of Cell Motility: From Molecules to Organisms, published by Wiley. Michelle Peckham is the editor of Cell Motility: From Molecules to Organisms, published by Wiley. Peter Clark is the editor of Cell Motility: From Molecules to Organisms, published by Wiley.

Preface.

List of contributors.

1. Molecular mechanisms regulating actin filament dynamics at
the leading edge of motile cells (Thomas D. Pollard).

2. The Role of Talin and Myosin VII in Adhesion - A FERM
Connection (Margaret A. Titus).

3. Do class I myosins exert their functions through regulation
of actin dynamics? (Thierry Soldati and Claudia Kistler).

4. Ephrin regulated contact repulsion of growth cones (Lene K.
Harbott, Daniel J. Marston and Catherine D. Nobes).

5. Interplay between the actin cytoskeleton, focal adhesions,
and microtubules (Christoph Ballestrem, Natalia Magid, Julia Zonis,
Michael Shtutman, and Alexander Bershadsky).

6. Initial Steps from cell migration to cell-cell adhesion
(Jason S. Ehrlich,W. James Nelson and Marc D. H. Hansen).

7. Using bioprobes to follow protein dynamics in living cells
(Mark R. Holt, Daniel Y.H. Soong, James Monypenny, Ian M. Dobbie,
Daniel Zicha and Graham A. Dunn).

8. Actin Filament Assembly: The Search for a Barbed End (Craig
F. Stovold, Stewart J. Sharp and Laura M. Machesky).

9. Role of WASP family proteins in cytoskeletal reorganization
and cell motility (Tadaomi Takenawa and Shiro Suetsugu).

10. Regulation and function of the small GTP-binding protein
ARF6 in membrane dynamics (Thierry Dubois, Emma Colucci-Guyon,
Florence Niedergang, Magali Prigent and Philippe Chavrier).

11. Chemotaxis of cancer cells during invasion and metastasis
(John Condeelis, Xiaoyan Song, Jonathan M. Backer, Jeffrey Wyckoff
and Jeffrey Segall).

12. Dynamin and cytoskeletal-dependent membrane processes (James
D. Orth, Noah W. Gray, Heather M. Thompson and Mark A.
McNiven).

13. Regulation of microtubule dynamics in migrating cells: a new
role for Rho GTPases (Torsten Wittmann and Clare M.
Waterman-Storer).

14. Calpain regulation of cell migration (Anna
Huttenlocher).

15. Role of villin in the dynamics of actin microfilaments
(Rafika Athman, Sylvie Robine and Daniel Louvard).

16. Scar, WASP and the Arp2/3 complex in dictyostelium
migration (Simone Blagg and Robert Insall).

17. Directional sensing: subcellular targeting of GPCR
downstream effectors during chemotaxis (Satoru Funamoto and Richard
A. Firtel).

18. Cell crawling, cell behavior and biomechanics during
convergence and extension (Ray Keller and Lance Davidson).

19. Regulation of cell migration in vitro and in
vivo (Donna J. Webb, Karen Donais, Shin-ichi Murase, Hannelore
Asmussen and Alan F. Horwitz).

20. Genes that control cell migration during mouse development
(Carmen Birchmeier).

Index.

"...very well written and referenced, and many chapters contain
excellent figures...this excellent volume will be a very useful
reference for several years to come." (The Quarterly Review of
Biology, December 2004)

"...remarkably up to date...should prove an invaluable
resource..." (Nature Cell Biology, August 2004)

Erscheint lt. Verlag 11.4.2005
Sprache englisch
Themenwelt Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
Technik
Schlagworte Biochemie • Biowissenschaften • Cell & Molecular Biology • Life Sciences • Molekularbiologie • Zell- u. Molekularbiologie
ISBN-10 0-470-09409-5 / 0470094095
ISBN-13 978-0-470-09409-9 / 9780470094099
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