Nuclear Organization in Development and Disease (eBook)

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: Robert D. Goldman

Chair's Introduction (R. Goldman).

Nuclear lamins: building blocks of nuclear structure and
function (R. Goldman, et al.).

Aspects of nuclear envelope dynamics in mitotic cells (B. Burke,
et al.).

Components of the nuclear envelope and their role in human
disease (H. Worman).

Nuclear membrane protein emerin: roles in gene regulation, actin
dynamics and human disease (K. Wilson, et al.).

Identification of novel integral membrane proteins of the
nuclear envelope with potential disease links using subtractive
proteomics (E. Schirmer, et al.).

Genetics of laminopathies (R. Ben Yaou, et al.).

Muscular dystrophies related to the cytoskeleton/nuclear
envelope (K. Nowak, et al.).

Skeletal and cardiac muscle defects in a murine model of
Emery-Dreifuss muscular dystrophy (M. Grattan, et al.).

Multiple pathways tether telomeres and silent chromatin at the
nuclear periphery: functional implications for Sir-mediated
repression (A. Taddei, et al.).

A-type lamin-linked lipodystrophies (C. Vigouroux and J.
Capeau).

Cytoskeletal defects in amyotrophic lateral sclerosis (motor
neuron disease) (J. Julien, et al.).

LMNA mutations in progeroid syndromes (S. Huang, et
al.).

A genetic approach to study the role of nuclear envelope
components in nuclear positioning (D. Starr and M. Han).

General Discussion I.

A lamin-dependent pathway that regulates nuclear organization,
cell cycle progression and germ cell development (A. Margalit, et
al.).

Mutations in the mouse Lmna gene causing progeria,
muscular dystrophy and cardiomyopathy (S. Kozlov, et al.).

The nuclear membrane and mechanotransduction: impaired nuclear
mechanics and mechanotransduction in lamin A/C-deficient cells (J.
Lammerding and R. Lee).

Chair's summing up (R. Goldman).

Index of contributors.

Subject index.

"...an excellent guide to research in the field of nuclear organization, and an encouragement for students interested in learning how great minds tackle complex problems." (Doody's Health Services)