Dendrimer–Based Drug Delivery Systems – From Theory to Practice

YIYUN CHENG, PhD, is a Full Professor of Biomedical Engineering at the School of Life Science of East China Normal University. His research interests focus on the biomedical applications of dendrimers and other dendritic polymers. Dr. Cheng has published more than forty peer-reviewed manuscripts in such journals as Nature Materials, Chemical Society Reviews, and Journal of the American Chemical Society.

Foreword vii Donald A. Tomalia Preface ix Acknowledgments xi Contributors xiii About the Editor xvii 1 Dendrimer Chemistry: Supramolecular Perspectives and Applications 1 Charles N. Moorefield, Sujith Perera, and George R. Newkome 2 Physicochemical Properties of Dendrimers and Dendrimer Complexes 55 Toyoko Imae 3 The Use of Dendrimers to Optimize the Physicochemical and Therapeutic Properties of Drugs 93 Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp, and Melgardt M. de Villiers 4 Biological Properties of Phosphorus Dendrimers 139 Anne-Marie Caminade and Jean-Pierre Majoral 5 Dendrimer-Based Prodrugs: Synthesis and Biological Evaluation 157 Mohammad Najlah, Zhengyuan Zhou, and Antony D'Emanuele 6 Improving the Biocompatibility of Dendrimers in Drug Delivery 207 Yiwen Li, Libo Zhao, and Yiyun Cheng 7 Degradable Dendrimers for Drug Delivery 239 Marc Gingras and Myriam Roy 8 Design of Stimuli-Responsive Dendrimers for Biomedical Purposes 307 Chie Kojima 9 Dendrimer-Based Gene Delivery Systems: Administration Routes and In Vivo Evaluation 329 Santander-Ortega M.J., Uchegbu I.F., and Scha¨tzlein A.G. 10 Triazine Dendrimers for DNA and siRNA Delivery: Progress, Challenges, and Opportunities 355 Meredith A. Mintzer, Olivia M. Merkel, Thomas Kissel, and Eric E. Simanek 11 Dendrimer-Coated Carbohydrate Residues as Drug Delivery Trojan Horses in Glycoscience 407 Yoann M. Chabre and Rene' Roy 12 Nuclear Magnetic Resonance Techniques in the Analysis of Pamam Dendrimer-Based Drug Delivery Systems 439 Xueyan Feng, Kun Yang, Jingjing Hu, Tongwen Xu, and Yiyun Cheng 13 Dendrimer-Based Medical Nanodevices for Magnetic Resonance Imaging Applications 463 Hongdong Cai, Mingwu Shen, and Xiangyang Shi 14 Dendrimer-Related Nanoparticle System for Computed Tomography Imaging 479 Chen Peng and Xiangyang Shi Index 501