Annual Plant Reviews, Functions and Biotechnology of Plant Secondary Metabolites (eBook)

Michael Wink is Professor of Pharmaceutical Biology and Director at the Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Germany

List of contributors

Preface

1 Introduction

Michael Wink

1.1 Ecological function of secondary metabolites

1.2 Presence of defence and signal compounds at the right time
and place

1.3 Molecular modes of action of SM

1.4 Biotechnology and utilization of SM

1.5 Conclusions

2 Molecular Modes of Action of Defensive Secondary
Metabolites

Michael Wink and Oskar Schimmer

2.1 Introduction

2.2 Molecular modes of action - an overview

2.3 Accumulation of defence and signal compounds in plants

2.4 Animal responses: detoxification mechanisms and
adaptations

2.5 Concluding remarks

3 Chemical Defence in Marine Ecosystems

Annika Putz and Peter Proksch

3.1 Introduction

3.2 Marine natural products in allelopathic interactions

3.3 Chemical defence against fouling

3.4 Chemical defences of marine invertebrates and algae against
consumers

3.5 Favoured allocation of defensive metabolites in vulnerable
and valuable parts of marine invertebrates and algae

3.6 The flexible response: stress-induced accumulation of
defence metabolites and activation of protoxins

3.7 Endosymbionts as sources for allelochemicals found in marine
invertebrates

3.8 Conclusions and outlook

4 Plant-Microbe Interactions and Secondary Metabolites
with Antibacterial, Antifungal and Antiviral Properties

Jürgen Reichling

4.1 Introduction

4.2 Phytoalexins

4.3 Antibacterial and antifungal agents of higher plants

4.4 Secondary metabolites from higher plants with antiviral
properties

4.5 Conclusions

5 New Medical Applications of Plant Secondary Metabolites

Jörg Heilmann

5.1 Introduction

5.2 Compounds with anticancer and chemopreventive activity

5.3 Antiviral compounds

5.4 Antimalarial drugs

5.5 Anti-inflammatory drugs

5.6 Antidepressant drugs

5.7 Anti-ischaemic drugs

5.8 Immunostimulatory drugs

5.9 Conclusions

6 Production of Natural Products by Plant Cell and Organ
Cultures

August-Wilhelm Alfermann

6.1 Introduction

6.2 Production of natural products by cell and organ
cultures

6.3 Elicitation

6.4 Increase/decrease of product yields by genetic
manipulation

6.5 Biosynthetic pathways delineation using RNA-interference

6.6 Mass cultivation of plant cell cultures

6.7 Production of recombinant proteins by plants and plant cell
cultures

6.8 Production of plant natural products in microbes

6.9 Perspectives

Index