Polymorphism (eBook)

After gaining his PhD in physical chemistry from Basel University, Switzerland, Rolf Hilfiker did his postdoc at Stony Brook, USA. He returned to Basel as a research fellow, initially at the university and then at Ciba-Geigy. In 1997 he became head of Stability & Kinetics group at Novartis, joining Solvias two years later where he is currently head of the department Solid-State Development. Dr. Hilfiker has taught physical chemistry in New York and Basel, and is a recipient of the Jacottet-Küng Award and a Treubel Fellowship. He is author of more than 50 scientific publications in various areas of physical chemistry.

Relevance of Solid-state Properties for Pharmaceutical Products
Thermodynamics of Polymorphs
Characterization of Polymorphic Systems using Thermal Analysis
Solid-state NMR Spectroscopy
Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization
Crystallography for Polymorphs
Light Microscopy
The Importance of Solvates
Physical Characterization of Hygroscopicity in Pharmaceutical Solids
The Amorphous State
Approaches to Polymorphism Screening
Salt Selection
Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality
Polymorphism and Patents from A Chemist's Point of View
Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications Relevance of Solid-state Properties for Pharmaceutical Products
Thermodynamics of Polymorphs
Characterization of Polymorphic Systems using Thermal Analysis
Solid-state NMR Spectroscopy
Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization
Crystallography for Polymorphs
Light Microscopy
The Importance Solvates
Physical Characterization of Hygroscopicity in Pharmaceutical Solids
The Amorphous State
Approaches to Polymorphism Screening
Salt Selection
Processing-induced Phase Transformations and their Implications on Pharmaceutical Product Quality
Polymorphism and Patents from A Chemist's Point of View
Scientific Considerations of Pharmaceutical Solid Polymorphism in Regulatory Applications

"...the book should be warmly welcomed and widely read. I shall frequently want to refer to it myself, and it will be particularly valuable to students learning about the subject. The latter advantage is especially important, given that most undergraduate courses in chemistry seem to ignore polymorphism, in spite of the fact that it is a ubiquitous phenomenon and is of critical industrial importance. The text of the book is generally clearly written and the illustrations are very helpful. The index is useful and the table of contents is very clearly set out. I recommend the book to a wide range of readership in the pharmaceutical industry and in academia - indeed, to all chemists interested in the characterization of solid organic compounds."
Angewandte Chemie

"...ist dem Buch ein großer Leserkreis zu wünschen, und vor allem für Studierende wird die Lektüre ein großer Gewinn sein, da in den meisten Grundvorlesungen der Chemie das Thema Polymorphie ausgelassen wird. Darüber hinaus ist es Wissenschaftlern in der pharmazeutischen Industrie und an Hochschulen, die sich für die Charakterisierung organischer Festkörper interessieren, sehr zu empfehlen." Angewandte Chemie