Whole Organ Approaches to Cellular Metabolism

1. Introduction.- 1. Modeling in the Analysis of the Processes of Uptake and Metabolism in the Whole Organ.- 2. Mechanisms of Endothelial Transport, Exchange, and Regulation.- 2. Transport Functions of the Glycocalyx, Specific Proteins, and Caveolae in Endothelium.- 3. Study of Blood Capillary Permeability with the Rete Mirabile.- 4. Interactions Between Bovine Adrenal Medulla Endothelial and Chromaffin Cells.- 5. Studies of the Glomerular Filtration Barrier: Integration of Physiologic and Cell Biologic Experimental Approaches.- 6. Endothelial Barrier Dynamics: Studies in a Cell-Column Model of the Microvasculature.- 3. Metabolism in the Heart and Skeletal Muscle.- 7. Strategies for Uncovering the Kinetics of Nucleoside Transport and Metabolism in Capillary Endothelial Cells.- 8. Norepinephrine Kinetics in Normal and Failing Myocardium: The Importance of Distributed Modeling.- 9. Metabolic Response Times: A Generalization of Indicator Dilution Theory Applied to Cardiac O2 Consumption Transients.- 10. Quantitative Assessment of Sites of Adenosine Production in the Heart.- 11. Role of Capillary Endothelial Cells in Transport and Metabolism of Adenosine in the Heart: An Example of the Impact of Endothelial Cells on Measures of Metabolism.- 12. Distribution of Intravascular and Extravascular Resistances to Oxygen Transport.- 4. Metabolism in the Liver.- 13. Liver Cell Entry In Vivo and Enzymic Conversion.- 14. Probing the Structure and Function of the Liver with the Multiple-Indicator Dilution Technique.- 15. A Generalized Mathematical Theory of the Multiple-Indicator Dilution Method.- 16. Impact of Extracellular and Intracellular Diffusion on Hepatic Uptake Kinetics.- 5. Metabolism in the Lung.- 17. The Uptake and Metabolism of Substrates by Endothelium in the Lung.- 18. Pulmonary Endothelial Surface Reductase Kinetics.- 19. Water and Small Solute Exchanges in the Lungs.- 20. Pulmonary Perfusion and the Exchange of Water and Acid in the Lungs.- 21. The Transport of Small Molecules Across the Microvascular Barrier as a Measure of Permeability and Functioning Exchange Area in the Normal and Acutely Injured Lung.- 22. Lipophilic Amines as Probes for Measurement of Lung Capillary Transport Function and Tissue Composition Using the Multiple-Indicator Dilution Method.- Publications of Carl A. Goresky.