Neuropeptides in Neuroprotection and Neuroregeneration -

Neuropeptides in Neuroprotection and Neuroregeneration

Fred Nyberg (Herausgeber)

Buch | Hardcover
320 Seiten
2012
Crc Press Inc (Verlag)
978-1-4398-3062-8 (ISBN)
218,20 inkl. MwSt
Although the genomic era is no longer in its infancy, the life sciences are still facing questions about the role of endogenous proteins and peptides in homeostasis and pathologies. Delving into one of the most current fields of interest in biology and medicine, Neuropeptides in Neuroprotection and Neuroregeneration describes the impact of neuropeptides on neuroprotection and neuroregeneration.



The book begins with chapters describing important features of the endogenous neuropeptide systems related to their formation, receptor signaling, and inactivation. It includes chapters focused on the design and development of peptide-like drugs (peptidomimetics). In addition, the book covers:










General aspects regarding the biosynthesis, structures, and distribution of neuroactive peptides and their receptors



Basic mechanisms for neuropeptide action, metabolism, as well as techniques for their detection and aspects essential for the cellular mechanisms underlying brain pathology



Neuropeptides known for their impact in neurodegenerative and neuroprotective processes



Fundamental aspects as well as recent progress in the development of peptidomimetics of neuroprotective and cognition-enhancing peptides

Fred J. Nyberg

The Neuropeptide Systems—Some Basic Concepts. Neuropeptide Biosynthesis. Neuropeptide Degradation Related to the Expression of Physiological Action of Neuropeptide. Neuropeptides, Isolation, Identification, and Quantitation. Cellular and Molecular Processes of Neuronal Damage and Protective Mechanisms in Neuroprotection and Neuroregeneration. What General Messages Can We Learn from the Situation after Brain Ischemia?. Dynorphins in Central Nervous System Pathology. Postnatal Stress Procedures Induce Long-Term Endocrine and Metabolic Alterations Involving Different Proopiomelanocortin-Derived Peptides. Prothymosin α—A Novel Endogenous Neuroprotective Polypeptide against Ischemic Damages. Influence of Anabolic Androgenic Steroids on Dynorphinergic Pathways in the Rat Brain. Angiotensin II Receptors and Neuroprotection. PACAP and Cellular Protection: Cellular Protection by Members of the VIP/Secretin Family with an Emphasis on Pituitary Adenylate Cyclase-Activating Polypeptide. General Strategies of Peptide Synthesis. Addressing the Interactions between Opioid Ligands and Their Receptors: Classic and Nonclassic Cases. Use of Peptides as Drug Leads—A Case Story on the Development of Dipeptides Corresponding to the Heptapeptide Substance P(1-7), with Intriguing Effects on Neuropathic Pain. Cognition-Enhancing Peptides and Peptidomimetics.

Verlagsort Bosa Roca
Sprache englisch
Maße 156 x 234 mm
Gewicht 566 g
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Technik
ISBN-10 1-4398-3062-2 / 1439830622
ISBN-13 978-1-4398-3062-8 / 9781439830628
Zustand Neuware
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