Optical Biosensors (eBook)

Cover 1
Table of Contents 8
Preface 10
List of Contributors 12
PART I OPTICAL BIOSENSORS: TODAY 22
Chapter 1 Optrode-based fiber optic biosensors (bio-optrode) 24
1.1. Principle of operation 25
1.2. History 55
1.3. State of the art for bio-optrodes 56
1.4. Advantages and limitations of bio-optrode technology 86
1.5. Potential for improving performance or expanding current capabilities 87
References 94
Chapter 2 Evanescent wave fiber optic biosensors 104
2.1. Technical concept 104
2.2. History 127
2.3. State of the art 128
2.4. Advantages and limitations 146
2.5. Future of evanescent fiber optic biosensors 150
Acknowledgements 153
References 153
Chapter 3 Planar waveguides for fluorescence biosensors 160
3.1. Technical concept 161
3.2. History 175
3.3. State of the art 179
3.4. Advantages and limitations for use in optical biosensing 190
3.5. Potential for improving performance or expanding current capabilities 191
Acknowledgements 197
References 197
Chapter 4 Surface plasmon resonance biosensors 206
4.1. Technical concept 206
4.2. History 231
4.3. State of the art 232
4.4. Advantages and limitations of SPR biosensors 254
4.5. Potential for expanding current capabilities 256
References 258
Chapter 5 Flow immunosensors 264
5.1. Principles of operation 265
5.2. History of the displacement immunosensor 270
5.3. Applications/implementation of the displacement immunosensor 278
5.4. History of the kinetic exclusion sensor 285
5.5. Advantages and limitations 295
5.6. Future potential 299
Acknowledgments 302
References 302
Chapter 6 Fluorescence lifetime biosensing: Entering the mainstream 308
6.1. Technical concept 308
6.2. History 319
6.3. State of the art 323
6.4. Advantages and limitations for use in optical biosensing 329
6.5. Potential for improving performance or expanding current capabilities 332
References 335
Chapter 7 Electrochemiluminescence 338
7.1. Principles of operation 338
7.2. History 352
7.3. State of the art 361
7.4. Advantages and limitations 375
7.5. Potential for expanding current capabilities 376
References 391
Chapter 8 Plasmonic SERS molecular sentinels: A new biosensing approach 406
8.1. Technical concept 407
8.2. History 410
8.3. State of the art 414
8.4. Advantages and limitations for use in optical biosensing 416
8.5. Potential for improving performance or expanding current capabilities 417
Acknowledgments 419
References 419
PART II OPTICAL BIOSENSORS: TOMORROW 422
Chapter 9 Cavity ring-down biosensing 424
9.1. Technical concept 424
9.2. History 431
9.3. State of the art 434
9.4. Potential for improving performance or expanding current capabilities 437
References 438
Chapter 10 Cantilever biosensors 440
10.1. Technical concept 440
10.2. History 454
10.3. State of the art 455
10.4. Advantages and limitations for use in optical biosensing 467
10.5. Potential for improving performance or expanding current capabilities 469
Acknowledgements 470
References 470
Chapter 11 Protein microarray technologies: An array of applications 474
11.1. Technical concept 475
11.2. Historical background 480
11.3. Applications for protein microarrays 481
11.4. Advantages and limitations of protein microarrays 485
References 486
Chapter 12 Single-domain antibodies: Rugged recognition elements for tomorrow’s biosensors 490
12.1. Technical concept 491
12.2. History 493
12.3. State of the art 500
12.4. Advantages and limitations for use in optical biosensing 508
12.5. Potential for improving performance or expanding current capabilities 509
Acknowledgements 510
References 510
Chapter 13 Nucleic acids for reagentless biosensors 514
13.1. The concept of a reagentless biosensor 515
13.2. History – in vitro selection 516
13.3. State of the art 522
13.4. Advantages and limitations 546
13.5. Potential for improving performance 548
References 556
Chapter 14 Imprinted polymers and their application in optical sensors 564
14.1. Molecular imprinting: technical concepts 565
14.2. Development of MIP-based optical sensors: history and state of the art 581
14.3. Market potential of MIP sensors and future prospects 595
14.4. New developments 596
References 598
Chapter 15 Nanoparticles for biosensors 604
15.1. Technical concepts 605
15.2. State of the art 613
15.3. Advantages and disadvantages 633
15.4. Future perspectives 635
References 637
Chapter 16 Fluorescence-based intracellular sensing 644
16.1. Technical concepts 644
16.2. History 650
16.3. State of the art 655
16.4. Advantages and limitations for use in optical biosensing 668
16.5. Potential for improving performance or expanding current capabilities 670
Acknowledgements 673
References 673
Chapter 17 Microfluidics 680
17.1. Technical concept 680
17.2. History 685
17.3. State of the art 686
17.4. Advantages and limitations for use in optical biosensing 698
17.5. Potential for improving performance or expanding current capabilities 699
References 700
Index 704
Color Plates 710