Cytokine Handbook, Two-Volume Set (eBook)

Michael T. Lotze, Angus W. Thomson (Herausgeber)

eBook Download: EPUB | PDF

2003 | 4. Auflage
1572 Seiten
Elsevier Science (Verlag)
978-0-08-051879-4 (ISBN)

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses.
Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.

Key Features
* Covers all main cytokines and chemokines
* Written by experts
* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome
* The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters
* Includes major emphasis on clinical applications
* Extensively illustrated with tables and figures

The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures

Cover 1
The Cytokine Handbook 4
Copyright Page 5
Contents 6
Preface to the First Edition 13
Preface to the Second Edition 16
Preface to the Third Edition 18
Preface to the Fourth Edition 20
Foreword 24
Section I: Basic Cytokine Biology 30
Chapter 1. The cytokines: an overview 32
Chapter 2. Cytokine genetics – Polymorphisms, functional variations and disease associations 48
Chapter 3. The phylogeny of cytokines 86
Chapter 4. Cytokine signaling 114
Section II: The Cytokines and Chemokines 128
Subsection A. The Hematopoietin Family Members 130
Chapter 5. Growth hormone 132
Chapter 6. Prolactin 144
Chapter 7. Erythropoietin 178
Chapter 8. Interleukin-2 196
Chapter 9. Interleukin-3 230
Chapter 10. Interleukin-4 256
Chapter 11. Interleukin-5 292
Chapter 12. Interleukin-6 Family 310
Chapter 13. Interleukin-7 334
Chapter 14. Interleukin-9 376
Chapter 15. Interleukin-11 392
Chapter 16. Interleukin-12 Family: [IL-12, 23, 12RA and 27] 412
Chapter 17. Interleukin-13 438
Chapter 18. Interleukin-15 and 21 460
Chapter 19. Interleukin-16 494
Chapter 20. Interleukin-17 Family [IL-17, IL-25] 504
Chapter 21. Granulocyte-macrophage colony-stimulating factor 532
Chapter 22. Granulocyte colony-stimulating factor 554
Subsection B. The Interferon Family Members 576
Chapter 23. Type I interferons [IFNa,B, d, k, w, t, IL-28A (IFNk2) IL-28B (IFNk3) and IL-29 (IFNk1)] 578
Chapter 24. Interferon-y 596
Chapter 25. Interleukin-10 632
Chapter 26. The IL-10 Family [Interleukins -19, -20, -22, -24 and -26] 656
Color Plate Section Volume 1 668
Section II: The Cytokines and Chemokines (continued) 682
SubSection C. The Beta Trefoil Cytokines and Proinflammatory Signaling Receptors 684
Chapter 27. Interleukin-1 Family [IL-1F1,F2] 686
Chapter 28. Interleukin-1 receptor antagonist [IL-1F3] 712
Chapter 29. Interleukin-18 [IL-1F4] 752
Chapter 30. Interleukin 1 Family [F5 to F10] 778
Chapter 31. The fibroblast growth factors 790
Chapter 32. Hepatocyte growth factor and its receptor, MET 826
Chapter 33. Toll-like receptors 852
SubSection D. The TNF Family, Receptors, and Related Molecules 866
Chapter 34. Lymphotoxins 868
Chapter 35. Tumor necrosis factor 880
Chapter 36. TRAIL/Apo2L 904
Chapter 37. RANKL (Receptor activator of NFkB ligand) 914
Chapter 38. CD95L/FasL and its receptor CD95 (APO-1/Fas) 928
Chapter 39. HMGB-1 956
SubSection E. The Tyrosine Kinase Receptor Signaling Molecules 968
Chapter 40. Macrophage Colony Stimulating Factor [CSF-1] 970
Chapter 41. EGF family ligands 1002
Chapter 42. FLT3 ligands 1032
Chapter 43. Stem cell factor 1054
Chapter 44. Vascular endothelial growth factor 1060
SubSection F. The Chemokines and other Cell Migration Regulating Factors 1078
Chapter 45. Macrophage migration inhibitory factor (MIF) 1080
Chapter 46. Interleukin-8 and other CXC chemokines 1092
Chapter 47. CC chemokines 1126
Chapter 48. Fractalkine 1144
SubSection G. The TGF Beta Family Members 1160
Chapter 49. Transforming growth factor B 1162
Chapter 50. The activin/inhibin family 1196
Chapter 51. Bone morphogenic proteins 1222
Section III: Clinical Application of Cytokines and Cytokine Inhibition 1230
Chapter 52. Autoimmunity and cytokines: pathogenesis and therapy 1232
Chapter 53. Cytokines and cancer 1256
Chapter 54. Interferon a: biology, pharmacology and therapy for chronic viral hepatitis 1276
Chapter 55. Haemopoietic cytokines 1298
Chapter 56. Antiangiogenesis and proangiogenic 1322
Chapter 57. Cytokines and transplantation 1340
Chapter 58. Cytokines and asthma 1356
Chapter 59. Cytokine gene transfer 1378
Chapter 60. Antisense therapy 1392
Chapter 61. Assays for cytokines 1418
Index 1440
Color Plate Section Volume 2 1480

Erscheint lt. Verlag	22.4.2003
Sprache	englisch
Themenwelt	Schulbuch / Wörterbuch ► Lexikon / Chroniken
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin
	Studium ► Querschnittsbereiche ► Infektiologie / Immunologie
	Naturwissenschaften ► Biologie ► Biochemie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Naturwissenschaften ► Physik / Astronomie ► Angewandte Physik
	Technik ► Umwelttechnik / Biotechnologie
ISBN-10	0-08-051879-6 / 0080518796
ISBN-13	978-0-08-051879-4 / 9780080518794

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