Advances in Drug Research (eBook)

Cover 1
Advances in Drug Research 4
Copyright Page 5
Contents 6
Contributors 8
Preface: Farewell 9
Chapter 1. The Concept o f Emergence–Dissolvence in Drug Research 12
1 Introduction 12
2 The Synergetic Process in the Formation of Complex Systems 13
3 The Concept of Dissolvence 15
4 Dissolvence at the Molecular Level 16
5 Dissolvence at the Biological Level 18
6 Dissolvence at the Pharmacological Level 20
7 Conclusion 24
References 25
Chapter 2. Sense and Non-sense in Toxicity Assessment of Medicinal Products 26
1 Introduction 27
2 Cases of Sense or Non-sense in Toxicity Assessment 30
3 Reflection and Discussion 64
References 73
Chapter 3. The Concept of Chiral Conformers and its Significance in Molecular Pharmacology 84
1 Introduction 84
2 Ring Conformers 87
3 Conformers of Flexible Molecules 97
4 Conclusion 116
References 117
Chapter 4. Combinatorial Compound Libraries for Enhanced Drug Discovery Approaches 122
1 Introduction 123
2 Historical Background 124
3 Basic Principles of Combinatorial Technologies 125
4 Current Topics 150
5 Discussion 191
References 194
Appendix 207
Chapter 5. Reversal of Chloroquine Resistance in Malaria: A New Concept of Chemotherapy 212
1 Introduction 213
2 The Mechanism of Action o f Chloroquine 214
3 Current Status of Chloroquine Resistance 219
4 The Mechanism of Chloroquine Resistance in Plasmodia 221
5 Strategies for the Development of Chloroquine Resistance Reversal Agents 225
6 Conclusion 237
References 238
Subject Index 244
Cumulative Index of Authors 254
cumulative Index of Titles 258