Enzyme Kinetics and Mechanisms, Part E, Energetics of Enzyme Catalysis (eBook)
460 Seiten
Elsevier Science (Verlag)
978-0-08-049666-5 (ISBN)
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Cover 1
Table of Contents 6
Contributors to Volume 308 8
Preface 10
Volumes in Series 12
Section I: Energetic Coupling in Enzymatic Reactions 30
Chapter 1. Energetics of Substrate Binding, Catalysis, and Product Release 32
Chapter 2. Energy Coupling Through Molecular Discrimination: Nicotinate Phosphoribosyltransferase 57
Chapter 3. On the Advantages of Imperfect Energetic Linkage 77
Chapter 4. Reaction Dynamics of G-Protein Catalyzed Hydrolysis of GTP as Viewed by X-Ray Crystallographic Snapshots of Gia 1 99
Chapter 5. Energetics of Nucleotide Hydrolysis in Polymer Assembly/Disassembly: The Cases of Actin and Tubulin 122
Chapter 6. Fundamental Mechanisms of Substrate Channeling 140
Section II: Intermediates and Complexes in Catalysis 176
Chapter 7. Intermediates and Energetics in Pyruvate Phosphate Dikinase 178
Chapter 8. Raman Spectroscopic Studies of the Structures, Energetics, and Bond Distortions of Substrates Bound to Enzymes 205
Chapter 9. Crystallographic Analysis of Solvent-Trapped Intermediates of Chymotrypsin 230
Section III: Detection and Properties of Low-Barrier Hydrogen Bonds 246
Chapter 10. Nuclear Magnetic Resonance Methods for the Detection and Study of Low-Barrier Hydrogen Bonds of Enzymes 248
Chapter 11. Hydrogen Bonding in Enzymatic Catalysis: Analysis of Energetic Contributions 275
Chapter 12. Application of Marcus Rate Theory to Proton Transfer in Enzyme-Catalyzed Reactions 305
Section IV: Transition State Determination and Inhibitors 328
Chapter 13. Enzymatic Transition-State Analysis and Transition-State Analogues 330
Chapter 14. Determining Transition States from Kinetic Isotope Effects 384
Chapter 15. Computational Methods for Transition State and Inhibitor Recognition 427
Author Index 456
Subject Index 476
Color Plate Section 490
Erscheint lt. Verlag | 6.9.1999 |
---|---|
Mitarbeit |
Chef-Herausgeber: John N. Abelson, Melvin I. Simon |
Sprache | englisch |
Themenwelt | Naturwissenschaften ► Biologie ► Biochemie |
Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
Naturwissenschaften ► Biologie ► Zellbiologie | |
Technik | |
ISBN-10 | 0-08-049666-0 / 0080496660 |
ISBN-13 | 978-0-08-049666-5 / 9780080496665 |
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