Rise and Fall of Epithelial Phenotype (eBook)
248 Seiten
Springer US (Verlag)
978-0-387-28671-6 (ISBN)
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT).
The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
CONTENTS 5
EDITOR 10
CONTRIBUTORS 10
PREFACE 15
EMT Concept and Examples from the Vertebrate Embryo 20
Epithelium- Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development 31
The Neural Crest: A Model Developmental EMT 48
Epithelial-Mesenchymal Transfonnation in the Embryonic Heart 59
Epithelial- Extracellular Matrix (Cell-ECM) Interactions in Hydra 75
Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos 96
Change of Epithelial Fate: Lessons from Gastnilation in Drosophila 120
Cutaneous Wound Reepithelialization: A Partial and Reversible EMT 130
Epithelial-Mesenchymal Transitions in Human Cancer 154
Structural and Functional Regulation of Desmosomes 179
Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E- Cadherin 197
The Regulation of Catenins in Cancer 210
Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease 222
The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition 234
TGFb 3- Dependent Epithelial-Mesenchymal Transition 255
The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering 264
Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases 274
Wnt Signaling Networks and Embryonic Patterning 286
Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network 307
Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis 316
Index 335
| Erscheint lt. Verlag | 5.7.2007 |
|---|---|
| Reihe/Serie | Molecular Biology Intelligence Unit |
| Zusatzinfo | 248 p. 101 illus., 2 illus. in color. |
| Verlagsort | New York |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Zellbiologie | |
| Technik | |
| Schlagworte | carcinoma • Drosophila • Gastrulation • Hydra • Migration • Mouse • Regulation • transcription • Vertebrate |
| ISBN-10 | 0-387-28671-3 / 0387286713 |
| ISBN-13 | 978-0-387-28671-6 / 9780387286716 |
| Haben Sie eine Frage zum Produkt? |
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