Cancer Microenvironment and Therapeutic Implications (eBook)
XVI, 242 Seiten
Springer Netherlands (Verlag)
978-1-4020-9576-4 (ISBN)
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology.
This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.
The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don't always behave the same. Understanding and eradicating cancers will require an appreciation for cancer's ecology.This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery.The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
Contents 6
Contributors 8
List of Abbreviations 11
Introduction 12
Tumor Physiopathology and Microenvironment Genesis 13
Inflammation and Carcinogenesis: A Change in the Metabolic Process 14
Tumor Microenvironment: Aspects of Stromal- Parenchymal Interaction 30
Significance of Tumor Microenvironment on the Genesis of: Interstitial Fluid, Angiogenesis, Haemostatic/ Haemorheologic Abnormalities. Pathogenesis and Therapeutic Aspects 50
Cancer, Stem Cells and the Neoplastic Niche 73
Tumor Microenvironment, Therapeutic Perspectives and Strategies for Normalization 89
Barriers to Drug Delivery in Cancer: Clinical Implications 90
Hypoxia, Hyperthermia, Chemotherapy: Interactions and Opportunities 114
Effects of Molecularly Targeting Hypoxia in Oncology 126
Significance of the Tumour Microenvironment in Radiotherapy 145
Effects of Tumor Microenvironment on Immunity and Consequent Clinical Considerations 165
Effects of Tumor Microenvironment on Hyperthermia, Photodynamic and Nanotherapy 188
Targeting Tumour Vascularization from Bench to Bedside: Suggestions for Combination with Hyperthermia 209
New Indications for Established Drugs Able to Modify Tumour- Host Interactions 226
Index 246
| Erscheint lt. Verlag | 10.4.2009 |
|---|---|
| Zusatzinfo | XVI, 242 p. |
| Verlagsort | Dordrecht |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Technik | |
| Schlagworte | angiogenesis • Cancer • Cancer Microenvironment • Carcinogenesis • Cell • Chemotherapy • Hematology • hyperthermia • inflammation • Oncology • pathogenesis • Pathology • pathophysiology • radiotherapy • Stem Cell • Tumor |
| ISBN-10 | 1-4020-9576-7 / 1402095767 |
| ISBN-13 | 978-1-4020-9576-4 / 9781402095764 |
| Haben Sie eine Frage zum Produkt? |
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