Leading Pharmaceutical Innovation (eBook)

Preface for 2nd Edition 5
Preface for 1st Edition 9
Contents 13
I. Innovation: Key to Success in the Pharmaceutical Industry 16
The Productivity Paradox 16
The Blockbuster Imperative 19
High Risks in Drug Development 25
Strategies for Growth 27
Differentiation via Clinical Profiles 30
Entering the Market Quickly 31
Conclusions 32
II. The Industry Challenge: Do You Really Want to Be in This Business? 34
High Complexity of the Industry 34
How Attractive is the Pharmaceutical Industry? 37
Force 1: Bargaining Power of Suppliers 39
Force 2: Bargaining Power of Buyers 40
Force 3: Risk of Entry from Potential Competitors 41
Force 4: Threat of Substitute Products 42
Force 5: Rivalry among Established Companies 43
Force 6: The Regulators 43
Conclusions 45
III. The Science and Technology Challenge: How to Find New Drugs 48
Rise of the Biotechnology Industry: Boosting Innovation 48
High-Throughput Screening: Fail Earlier, Succeed Sooner 53
Combinatorial Chemistry: Cut Experimental Cycle Times 54
Bioinformatics: More than 100 Gigabytes of Data per Day 55
Proteomics: Profiting from the Human Genome Project 57
Genomics: Towards Individualization and Mass Customization 58
Pharmacogenomics: Create Tailor-made Drugs 60
Molecular Design: From Experimenting to Analytic Design 62
Conclusions 63
IV. The Pipeline Management Challenge: How to Organize Innovation 66
The Relevance of Pipeline Management 66
Complexity and Phases of the R& D Process
The Importance of Project and Portfolio Management 80
The Disaggregation of the Pharmaceutical Value Chain 83
Impact of Outsourcing on Pharmaceutical R& D
Rising Importance of R& D Collaborations
Research Alliances: Accessing Early-stage Innovation 93
In-licensing: Enhancing the Innovation Pipeline 96
Co-development: Mutually Benefiting from Joint Resources 98
Out-licensing: Commercializing Internal Research Results 101
How to Commercialize a Breakthrough Technology 110
Conclusions 115
V. The Internationalization Challenge: Where to Get Access to Innovation 118
Trends and Drivers of R& D Internationalization
Primary Locations of Pharmaceutical R& D around the World
New Opportunities for Drug Development in China 126
Three Principal Problems of Dispersed R& D
Conclusions 136
VI. Management Answers to Pharmaceutical R& D Challenges
Managing R& D Organization at Roche
Managing R& D Strategy at Schering
Managing the Research-to-Development Handover at Roche 142
Managing Outsourcing Activities at Solvias 145
Managing Intellectual Property Rights at Bayer 148
Managing Out-licensing at Novartis 152
Managing Uncertainty at Roche 159
Managing Global R& D at Major Swiss Pharma Companies
Managing a Niche-Market Strategy at Intarcia 166
Managing Virtual Project Management Pools at Roche 168
Conclusions 171
VII. Future Directions and Trends 174
Bibliography 180
Index 188
Glossary 194
Authors 200