Tissue Engineering (eBook)

Preface 6
Contents 7
Contributors 12
STEM CELLS 20
“STEM CELLS INTO LIVER”- BASIC RESEARCH AND POTENTIAL CLINICAL APPLICATIONS 21
MESENCHYMAL STEM CELLS INCREASE SELF-RENEWAL OF SMALL INTESTINAL EPITHELIUM AND ACCELERATE STRUCTURAL RECOVERY AFTER RADIATION INJURY 36
OPTIMIZING VIRAL AND NON-VIRAL GENE TRANSFER METHODS FOR GENETIC MODIFICATION OF PORCINE MESENCHYMAL STEM CELLS 48
TRANSPLANTATION OF BONE MARROW STROMAL CELLS FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES 66
SOLUBLE AND INSOLUBLE SIGNALS 82
CHONDROCYTE SIGNALING AND ARTIFICIAL MATRICES FOR ARTICULAR CARTILAGE ENGINEERING 83
OSTEOINDUCTION WITH COLLOSS®, COLLOSS® E, AND GFm 103
BIGLYCAN IS A POSITIVE MODULATOR OF BMP-2 INDUCED OSTEOBLAST DIFFERENTIATION 117
USE OF NEOPTERIN AS A BONE MARROW HEMATOPOIETIC AND STROMAL CELL GROWTH FACTOR IN TISSUE-ENGINEERED DEVICES 130
SCAFFOLDS AND MATRIX DESIGN 137
INJECTABLE SYNTHETIC EXTRACELLULAR MATRICES FOR TISSUE ENGINEERING AND REPAIR 138
TEMPORAL CHANGES IN PEG HYDROGEL STRUCTURE INFLUENCE HUMAN MESENCHYMAL STEM CELL PROLIFERATION AND MATRIX MINERALIZATION 147
NOVEL BIOPHYSICAL TECHNIQUES FOR INVESTIGATING LONG-TERM CELL ADHESION DYNAMICS ON BIOMATERIAL SURFACES 162
EVALUATION OF VARIOUS TYPES OF SCAFFOLD FOR TISSUE ENGINEERED INTERVERTEBRAL DISC 177
PHYSICOCHEMICAL CHARACTERIZATION OF PHOTOPOLYMERIZABLE PLGA BLENDS 192
POROUS TANTALUM TRABECULAR METAL SCAFFOLDS IN COMBINATION WITH A NOVEL MARROW PROCESSING TECHNIQUE TO REPLACE AUTOGRAFT 206
PREPARATION OF SPONGE USING PORCINE SMALL INTESINAL SUBMUCOSA AND THEIR APPLICATIONS AS A SCAFFOLD AND A WOUND DRESSING 218
BIOREACTOR AND ASSESSMENT TECHNOLOGIES 232
MODULATION OF CELL DIFFERENTIATION IN BONE TISSUE ENGINEERING CONSTRUCTS CULTURED IN A BIOREACTOR 233
BIOREACTORS FOR TISSUES OF THE MUSCULOSKELETAL SYSTEM 250
NON-INVASIVE MONITORING OF TISSUE-ENGINEERED PANCREATIC CONSTRUCTS BY NMR TECHNIQUES 267
ANIMAL MODELS AND CLINICAL STRATEGIES 283
FROM MOLECULES TO MATRIX: CONSTRUCTION AND EVALUATION OF MOLECULARLY DEFINED BIOSCAFFOLDS 284
AGE-RELATED DIFFERENCES IN ARTICULAR CARTILAGE WOUND HEALING: A POTENTIAL ROLE FOR TRANSFORMING GROWTH FACTOR ß1 IN ADULT CARTILAGE REPAIR 301
INTRINSIC VERSUS EXTRINSIC VASCULARIZATION IN TISSUE ENGINEERING 314
PREDICTIVE VALUE OF IN VITRO AND IN VIVO ASSAYS IN BONE AND CARTILAGE REPAIR — WHAT DO THEY REALLY TELL US ABOUT THE CLINICAL PERFORMANCE? 330
SCIENCE, REGULATION, AND THE PUBLIC 364
ENGINEERED TISSUES: THE REGULATORY PATH FROM CONCEPT TO MARKET 365
TISSUE ENGINEERING STRATEGIES 379
FIBRIN IN TISSUE ENGINEERING 380
ECTOPIC BONE INDUCTION BY EQUINE BONE PROTEIN EXTRACT 394
ADIPOSE TISSUE INDUCTION IN VIVO 404
OCULAR TISSUE ENGINEERING 414
MOLECULAR MECHANISM OF OSTEOCHONDROPROGENITOR FATE DETERMINATION DURING BONE FORMATION 431
Author Index 442
Subject Index 444