Basic Pharmacokinetics

Mohsen A. Hedaya, PharmD, PhD, is a professor at the Faculty of Pharmacy at Tanta University in Egypt, and is currently on leave to work at the Faculty of Pharmacy at Kuwait University. His research interests include pharmacokinetic drug interactions, drug delivery to the brain, pharmacokinetic computer simulations, bioequivalent study design and data analysis, and the development and assessment of computer-aided instructional materials in the area of pharmacokinetics. Dr. Hedaya is a member of numerous international scientific associations and has received several prestigious teaching and research achievement awards. He has to his credit extensive scientific publications in national and international journals and frequently gives presentations at national and international scientific meetings. The computer-based educational materials developed by Dr. Hedaya in the area of pharmacokinetics are currently being used by more than 300 educational, research, and industrial institutions around the world.

Introduction to Pharmacokinetics. Review of Mathematical Fundamentals. Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Distribution. Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance. Drug Pharmacokinetics Following a Single IV Bolus Administration: The Rate of Drug Elimination. Drug Absorption Following Extravascular Administration: Biological, Physiological, and Pathological Considerations. Drug Absorption Following Extravascular Administration: Molecular and Physicochemical Considerations. Drug Absorption Following Extravascular Administration: Formulation Factors. Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption. Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption. Bioequivalence. Drug Pharmacokinetics during Constant Rate IV Infusion: The Steady-State Principle. Steady State during Multiple Drug Administration. Renal Drug Excretion. Metabolite Pharmacokinetics. Nonlinear Pharmacokinetics. Multicompartment Pharmacokinetic Models. Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusion. Pharmacokinetic-Pharmacodynamic Modeling. Noncompartmental Approach in Pharmacokinetic Data Analysis. Physiological Approach to Hepatic Clearance. Physiologically Based Pharmacokinetic Models. Therapeutic Drug Monitoring. Pharmacokinetics in Special Patient Populations. Pharmacokinetic Drug-Drug Interactions. Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability. Applications of Computers in Pharmacokinetics. The Companion CD. Solutions for the Practice Problems. Index.