Mems for Biomedical Applications

Shekhar Bhansali is the Alcatel-Lucent Professor and the Chair of the Department of Electrical and Computer Engineering at Florida International University, USA. Abhay Vasudev is a Graduate Researcher at Florida International University’s bioMEMS and Microsystems Lab.

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Woodhead Publishing Series in Biomaterials

Introduction

Chapter 1: Microfabrication of polymers for bioMEMS

Abstract:

1.1 Introduction

1.2 Microfabrication

1.3 Polymers and processes

1.4 Conclusions

Chapter 2: Review of sensor and actuator mechanisms for bioMEMS

Abstract:

2.1 Introduction: transducers

2.2 Sensors

2.3 Actuators

2.4 Biomedical applications of sensors and actuators

2.5 Optical biosensor

2.6 Microrobotics in biomedical applications

2.7 Conclusion

Chapter 3: MEMS for in vivo sensing

Abstract:

3.1 Introduction

3.2 Overview of MEMS in vivo devices and sensors

3.3 Challenges and possible solutions to in vivo sensing methodology

3.4 Regulatory dimensions

3.5 Conclusions and future trends

Chapter 4: MEMS and electrical impedance spectroscopy (EIS) for non-invasive measurement of cells

Abstract:

4.1 Importance of MEMS in cellular assays

4.2 Impedimetric measurement theory

4.3 Visualization and modeling

4.4 Bioimpedance before MEMS: patch clamp measurements

4.5 MEMS in bioimpedance applications

4.6 Future trends

4.7 Sources of further information and advice

Chapter 5: MEMS ultrasonic transducers for biomedical applications

Abstract:

5.1 Introduction

5.2 Modeling and design of capacitive micromachined ultrasonic transducers (CMUTs)

5.3 Fabrication

5.4 Integration

5.5 Biomedical applications

5.6 Conclusion and future trends

Chapter 6: Lab-on-chip (LOC) devices and microfluidics for biomedical applications

Abstract:

6.1 Introduction

6.2 Pressure-driven lab-on-chip (LOC)

6.3 Capillary-driven LOC

6.4 Electrokinetic-driven LOC

6.5 Centrifugal-driven LOC

6.6 Droplet-based LOC

6.7 Electrowetting-based LOC

6.8 Future trends

Chapter 7: Fabrication of cell culture microdevices for tissue engineering applications

Abstract:

7.1 Introduction: cell culture microdevices

7.2 Motivation for microdevice development

7.3 Design and fabrication concepts for cell culture

7.4 Applications of cell culture microdevices

7.5 Future trends

7.6 Sources of further information and advice

Chapter 8: MEMS manufacturing techniques for tissue scaffolding devices

Abstract:

8.1 Introduction

8.2 Tissue scaffold design

8.3 Tissue scaffold fabrication using MEMS approaches

8.4 Applications of MEMS-fabricated tissue scaffold

8.5 Conclusion

Chapter 9: BioMEMs for drug delivery applications

Abstract:

9.1 Introduction

9.2 Transdermal delivery

9.3 Implantable systems

9.4 Microfabricated drug delivery vehicles

9.5 Conclusions

9.6 Acknowledgement

Chapter 10: Applications of MEMS technologies for minimally invasive medical procedures

Abstract:

10.1 Introduction

10.2 Microvisualization

10.3 Micromanipulation

10.4 Future trends and conclusions

Chapter 11: Smart microgrippers for bioMEMS applications

Abstract:

11.1 Introduction

11.2 Microgripping and release strategies

11.3 Microgripper demonstration: microcage

11.4 Conclusions

11.5 Acknowledgement

Chapter 12: Microfluidic techniques for the detection, manipulation and isolation of rare cells

Abstract:

12.1 Introduction

12.2 Size-based isolation

12.3 Mass-based isolation

12.4 Electrical-based isolation

Chapter 13: MEMS as implantable neuroprobes

Abstract:

13.1 Introduction – neuronal communication

13.2 MEMS-based neuronal intervention devices

13.3 Tissue response against implanted neural microelectrode interfaces

13.4 Implantable wireless recording integrated circuit (IC) challenges

Chapter 14: MEMS as ocular implants

Abstract:

14.1 Introduction

14.2 Implantable MEMS for glaucoma therapy

14.3 Integrated microsystems for artificial retinal implants

14.4 Future trends

14.5 Conclusion

Chapter 15: Cellular microinjection for therapeutic and research applications

Abstract:

15.1 Introduction

15.2 Significance of cellular injection

15.3 Microinjection

15.4 MEMS technologies for microinjection

15.5 Future of mechanical microinjection

15.6 Automating microinjection

15.7 Conclusion

Chapter 16: Hybrid MEMS: Integrating inorganic structures into live organisms

Abstract:

16.1 Introduction

16.2 Hybrid integration

16.3 Vacuum microfabrication on Drosophila

16.4 Conclusions and future trends

Index