Drug Design of Zinc–Enzyme Inhibitors – Functional Structural, and Disease Applications

Claudiu T. Supuran is a professor in the Department of Chemistry at the University of Florence, Italy. His main research interests include medicinal chemistry, design of enzyme inhibitors and activators, X-ray crystallography of metallo-enzymes, and metal complexes with biologically active ligands (metal-based drugs). He has published more than 400 original research papers in these fields. Jean-Yves Winum is an assistant professor in the Department of Chemistry at the University of Montpellier 2 (Institut des Biomolecules Max Mousseron UMR CNRS 5247), France. His research interests are focused on organic/medicinal chemistry of metallo-enzyme inhibitors and activators.

PREFACE. CONTRIBUTORS. PART I: INTRODUCTION. 1. Introduction to Zinc Enzymes as Drug Targets ( Claudiu T. Supuran and Jean-Yves Winum ). PART II: DRUG DESIGN OF CARBONIC ANHYDRASE INHIBITORS AND ACTIVATORS. 2. Carbonic Anhydrases as Drug Targets: General Presentation ( Claudiu T. Supuran ). 3. Zinc Binding Functions in the Design of Carbonic Anhydrase Inhibitors ( Jean-Yves Winum, Jean-Louis Montero, Andrea Scozzafava, and Claudiu T. Supuran ). 4. X-Ray Crystallography of Carbonic Anhydrase Inhibitors and Its Importance in Drug Design ( Vincenzo Alterio, Anna Di Fiore, Katia D'Ambrosio, Claudiu T. Supuran, and Giuseppina De Simone ). 5. Antiglaucoma Carbonic Anhydrase Inhibitors as Ophthalomologic Drugs ( Francesco Mincione, Andrea Scozzafava, and Claudiu T. Supuran ). 6. Diuretics with Carbonic Anhydrase Inhibitory Activity: Toward Novel Applications for Sulfonamide Drugs ( Daniela Vullo, Alessio Innocenti, and Claudiu T. Supuran ). 7. Drug Design of Carbonic Anhydrase Inhibitors as Anticonvulsant Agents ( Anne Thiry, Jean-Michel Dogn e, Claudiu T. Supuran, and Bernard Masereel ). 8. Carbonic Anhydrase Inhibitors Targeting Cancer: Therapeutic, Immunologic, and Diagnostic Tools Targeting Isoforms IX and XII ( Silvia Pastorekova, Monika Barathova, Juraj Kopacek, and Jaromir Pastorek ). 9. Fluorescent- and Spin-Labeled Sulfonamides as Probe for Carbonic Anhydrase IX ( Alessandro Cecchi, Laura Ciani, Sandra Ristori, and Claudiu T. Supuran ). 10. Drug Design of Antiobesity Carbonic Anhydrase Inhibitors ( Giuseppina De Simone and Claudiu T. Supuran ). 11. Dual Carbonic Anhydrase and Cyclooxygenase-2 Inhibition ( Jean-Michel Dogn e, Anne Thiry, Bernard Masereel, and Claudiu T. Supuran ). 12. Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV ( Mika Hilvo, Giuseppina De Simone, Claudiu T. Supuran, and Seppo Parkkila ). 13. Mechanism and Inhibition of the b-Class and c-Class Carbonic Anhydrases (James G. Ferry and Claudiu T. Supuran ). 14. Fungal and Nematode Carbonic Anhydrases: Their Inhibition in Drug Design ( Rebecca A. Hall and Fritz. A. MEURO uhlschlegel ). 15. Crystallographic Studies on Carbonic Anhydrases from Fungal Pathogens for Structure-Assisted Drug Development ( Uta-Maria Ohndorf, Christine Schlicker, and Clemens Steegborn ). 16. Malaria Parasite Carbonic Anhydrase and Its Inhibition in the Development of Novel Therapies of Malaria ( Jerapan Krungkrai, Sudaratana R. Krungkrai, and Claudiu T. Supuran ). 17. Inhibitors of Helicobacter pylori a- and b-Carbonic Anhydrases as Novel Drugs for Gastroduodenal Diseases ( Isao Nishimori, Hiroaki Takeuchi, and Claudiu T. Supuran ). 18. QSAR of Carbonic Anhydrase Inhibitors and Their Impact on Drug Design ( Adriano Martinelli and Tiziano Tuccinardi ). 19. Selectivity Issues in the Design of CA Inhibitors ( Claudiu T. Supuran and Jean-Yves Winum ). 20. Bicarbonate Transport Metabolons ( Danielle E. Johnson and Joseph R. Casey ). 21. Metal Complexes of Sulfonamides as Dual Carbonic Anhydrase Inhibitors ( Marc A. Ilies ). 22. Drug Design Studies of Carbonic Anhydrase Activators ( Claudia Temperini, Andrea Scozzafava, and Claudiu T. Supuran ). PART III DRUG DESIGN OF MATRIX METALLOPROTEINASE INHIBITORS. 23. Matrix Metalloproteinases: An Overview ( Hideaki Nagase and Robert Visse ). 24. MMP Inhibitors Based on Earlier Succinimide Strategies: From Early to New Approaches ( M. Amelia Santos ). 25. Drug Design of Sulfonylated MMP Inhibitors ( Armando Rossello and Elisa Nuti ). 26. ADAMs and ADAMTs Selective Synthetic Inhibitors ( Armando Rossello, Elisa Nuti, and Alfonso Maresca ). 27. QSAR Studies of MMP Inhibitors ( Tiziano Tuccinardi and Adriano Martinelli ). PART IV DRUG DESIGN OF BACTERIAL ZINC PROTEASE INHIBITORS. 28. Bacterial Zinc Proteases as Orphan Targets ( Claudiu T. Supuran ). 29. Botulinus Toxin, Tetanus Toxin, and Anthrax Lethal Factor Inhibitors ( Antonio Mastrolorenzo and Claudiu T. Supuran ). 30. Clostridium histolyticum Collagenase Inhibitors in the Drug Design ( Claudiu T. Supuran ). 31. Other Bacterial Zinc Peptidases as Potential Drug Targets ( Kunihiko Watanabe ). PART V DRUG DESIGN STUDIES OF OTHER ZINC-CONTAINING ENZYMES. 32. Angiotensin Converting Enzyme (ACE) Inhibitors ( Ana Camara-Artigas, Vicente Jara-Perez, and Montserrat Andujar-S anchez ). 33. P-III Metalloproteinase (Leucurolysin-B) from Bothrops leucurus Venom: Isolation and Possible Inhibition ( Eladio F. Sanchez and Johannes A. Eble ). 34. CaaX-Protein Prenyltransferase Inhibitors ( Martin Schlitzer, Regina Ortmann, and Mirko Altenk amper ). 35. Histone Deacetylase Inhibitors ( Paul W. Finn ). 36. Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII) ( Youngjoo Byun, Ronnie C. Mease, Shawn E. Lupold, and Martin G. Pomper ). 37. Targeting HIV-1 Integrase Zinc Binding Motif ( Mario Sechi, Mauro Carcelli, Dominga Rogolino, and Nouri Neamati ). 38. Inhibitors of Histidinol Dehydrogenases as Antibacterial Agents ( Pascale Joseph, FrancCois Turtaut, Stephan KEURO ohler, and Jean-Yves Winum ). 39. Dihydroorotase Inhibitors ( Mihwa Lee, Megan J. Maher, Richard I. Christopherson, and J. Mitchell Guss ). 40. APOBEC3G: A Promising Antiviral Target ( Claudiu T. Supuran and Jean-Yves Winum ). Index.