Ionic Liquid Applications: Pharmaceuticals, Therapeutics, and Biotechnology

Sanjay V. Malhotra is head of the Laboratory of Synthetic Chemistry, Developmental Therapeutic Program Support, SAIC-Frederick, National Cancer Institute-Frederick, Maryland.

Preface ; 1. Ionic Liquids as Pharmaceutical Salts: A Historical Perspective ; Vineet Kumar and Sanjay V. Malhotra ; 2. Ionic Liquids: New Opportunities for the Chemistry of Amino Acids, Peptides, and Pharmaceutical Compounds ; James Ternois, Laurent Ferron, Gerard Coquerel, Frederic Guillen, and Jean-Christophe Plaquevent ; 3. Enzymatic Membrane Reactor for Resolution of Ketoprofen in Ionic Liquids and Supercritical Carbon Dioxide Pedro Lozano, Teresa De Diego, Arturo Manjon, Miguel A. Abad, Michel Vaultier, and Jose L. Iborra ; 4. Development of a Universal Method Based on Ionic Liquids for Determination of Enantiomeric Compositions of Pharmaceutical Products ; Chieu D. Tran ; 5. New Method for Installation of the Imidazole Ring and Synthesis of Biologically Active Molecules with Ionic Liquid-Like Structures ; Yuichi Kobayashi, Yohei Kiyotsuka, Hukum P. Acharya, and Key Miyoshi ; 6. Separation and Recovery of Penicillin in an Integrated System Containing Ionic Liquids ; Yangyang Jiang, Chen Guo, Hansong Xia, and Huizhou Liu ; 7. Enzymatic Hydrolysis of Penicillin in an Integrated System Containing Ionic Liquids ; Yangyang Jiang, Chen Guo, Hansong Xia, and Huizhou Liu ; 8. Antitumor Activity of Ionic Liquids on Human Tumor Cell Lines ; Vineet Kumar and Sanjay V. Malhotra ; 9. Preparation of Ionic Liquid-Modified Inorganic Nanoparticles and Their Biomedical Application ; Asako Narita, Kensuke Naka, and Yoshiki Chujo ; 10. Preparation of Biopolymer-Based Materials Using Ionic Liquids for the Biomedical Application ; Sang Hyun Lee, Minoru Miyauchi, Jonathan S. Dordick, and Robert J. Linhardt ; 11. Toxicological Evaluation of Ionic Liquids ; Raquel F. M. Frade, Ana Matias, Luis C. Branco, Nuno M. T. Lourenco, Joao N. Rosa, Carlos A. M. Afonso, and Catarina M. M. Duarte ; 12. Formation of Anhydrosugars from Polysaccharides in Ionic Liquids by Microwave Irradiation ; Hiroe Satoh, Momoko Hayashi, Toshifumi Satoh, Toyoji Kakuchi, Harumi Kaga, and Kenji Takahashi ; 13. Chiral Pyrrolidine-Substituted Ionic Liquid-Mediated Activation of Enzyme ; Toshiyuki Itoh, Yoshikazu Abe, Takuya Hirakawa, Nagisa Okano, Shino Nakajima, Shuichi Hayase, Motoi Kawatsura, Tomoko Matsuda, and Kaoru Nakamura ; 14. Deep Eutectic Solvents for Candida antarctica Lipase B-Catalyzed Reactions ; Johnathan T. Gorke, Friedrich Srienc, and Romas J. Kazlauskas ; 15. Enzyme Catalysis in Ionic Liquids and Supercritical Carbon Dioxide ; Pedro Lozano, Teresa De Diego, Michel Vaultier, and Jose L. Iborra ; 16. On the Merge of Fungal Activity with Ionic Liquids towards the Development of New Biotechnological Processes ; M. Petkovic, J. Ferguson, A. Bohn, J. R. Trindade, I. Martins, C. Leitao, M. B. Carvalho, C. Rodrigues, H. Garcia, R. Ferreira, K. R. Seddon, L. P. N. Rebelo, and C. Silva Pereira