Clinical Aspects of Electroporation

Introduction to Electroporation.- Electroporation and cellular physiology.- The cell in the electric field.- Understanding Electric Fields for Clinical Use.- Generators and Applicators – Equipment for Electroporation.- Cell electropermeabilization and cellular uptake of small molecules: the electrochemotherapy concept.- Vascular-disrupting action of electrochemotherapy: mode of action and therapeutic implications.- Electrochemotherapy of small tumors; the experience from the ESOPE (European Standard Operating Procedures for Electrochemotherapy) group.- Electrochemotherapy for larger malignant tumors.- Cell electroporation in bone tissue.- Drug and Gene electrotransfer to the brain.- Minimally invasive intraluminal tumor ablation.- Electrotransfer of plasmid DNA.- Gene Electrotransfer to Tumor.- Gene electrotransfer to lung.- Gene electrotransfer to muscle tissue; moving into clinical use.- Gene electrotransfer to skin.- Electroporation-mediated DNA vaccination.- Irreversible Electroporation (IRE) on Liver Tumor Ablation: A Summary of Preclinical Translational Research.- Translational Research on Irreversible Electroporation – VX2 Rabbit Head and Neck.- Clinical Research on Irreversible Electroporation of the Liver