Alzheimer's Disease

Advances in Genetics, Molecular and Cellular Biology

Sangram S. Sisodia, Rudolph E. Tanzi (Herausgeber)

Buch | Softcover

286 Seiten

2010 | Softcover reprint of hardcover 1st ed. 2007
Springer-Verlag New York Inc.
978-1-4419-4195-4 (ISBN)

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This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

The Genetics of Alzheimer’s Disease.- APP Biology, Processing and Function.- The Biology of the Presenilin Complexes.- ?-secretase: Physiological Role and Target Validation.- Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer’s Disease.- Cholesterol and ?-Amyloid.- A? Structure and Aggregation.- Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction.- Beta Amyloid and Excitatory Synapses.- A? Degradation.- Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease.- Tau Gene Mutations in FTDP-17 Syndromes.- Animal Models of Tauopathy.- Tau and Axonal Transport.- Growth Factors in Alzheimer’s Disease.

Erscheint lt. Verlag	29.10.2010
Zusatzinfo	5 Illustrations, color; 19 Illustrations, black and white; X, 286 p. 24 illus., 5 illus. in color.
Verlagsort	New York, NY
Sprache	englisch
Maße	155 x 235 mm
Themenwelt	Medizin / Pharmazie ► Medizinische Fachgebiete ► Geriatrie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie
	Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie
	Medizin / Pharmazie ► Studium
	Naturwissenschaften ► Biologie ► Humanbiologie
	Naturwissenschaften ► Biologie ► Zoologie
	Technik ► Maschinenbau
ISBN-10	1-4419-4195-9 / 1441941959
ISBN-13	978-1-4419-4195-4 / 9781441941954
Zustand	Neuware