Proteomic and Genomic Analysis of Cardiovascular Disease

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Preface.List of Contributors.Section1: GENOMICS.Large Scale Expression Profiling in Cardiovascular Disease Using Microarrays: Prospects and Pitfalls (M. Schinke, et al.).Global Genomic Analyses of Cardiovascular Disease: A Potential Map or Blind Alley? (M. Krenz, et al.). Heart Failure: A Genomics Approach (C. Liew).Principles of cDNA Microarrays as Applied in Heart Failure Research (S. Arab, et al.).Gene Profiling in the Heart by Subtractive Hybridization (C. Depre).DNA Mircoarray Gene Profiling: A Tool for the Elucidation of Cardioprotective Genes (E. Murphy, et al.).Pitfalls Associated with cDNA Microarrays - A Cautionary Tale (A. Aplin & C. Murry).Application of Biologic Skepticism to Analysis of Expression Phenotypes (L. Adams, et al.).Genes Involved in Atherosclerosis and Plaque Formation (T. Tuomisto & S. Yl erttuala).Section 2: PROTEOMICS.Gene Expression Profiling in Pulmonary and Systemic Vascular Cells Exposed to Biomec hanical Stimuli (S. Ma, et al.).Proteomics, a Step Beyond Genomics: Applications to Cardiovascular Disease (E. McGregor & M. Dunn).Mass Spectrometry - A Powerful Analytical Tool (H. Byers & M. Ward).Differential Expression Proteomic Analysis Using Isotope Coded Affinity Tags (M. Wright & R. Aebersold). Protein Chip T echnology in Proteomics Analysis (R. Jenkins & S. Pennington).Recent Applications of Functional Proteomics: Investigations in Smooth Muscle Cell Physiology (J. MacDonald & T. Haystead).Identification of Targets of Phosphorylation in Heart Mitochondria (R. Gottlieb & H. He).Proteomic Characterization of Protein Kinase C Signaling Tasks in the Heart (T. Vondriska, et al.).Identification of Secreted Oxidative Stress-induced Factors (SOXF) and Associated Proteins: Proteomics in Vascular Biology (Z. Jin, et al.).Myofilament Proteomics: Understanding Contractile Dysfunction in Cardiorespiratory Disease (J. Simpson, et al.).Section 3: FUTURE PERSPECTIVES.Genomics Perspective for Drug Discovery (A. Marian & M. Gollob).Proteomics: A Post-Genomic Platform for Drug Discovery and Development (S. Rapundalo).Subject Index.