Multiscale Modeling of Cancer - Vittorio Cristini, John Lowengrub

Multiscale Modeling of Cancer

An Integrated Experimental and Mathematical Modeling Approach
Buch | Hardcover
298 Seiten
2010
Cambridge University Press (Verlag)
978-0-521-88442-6 (ISBN)
178,30 inkl. MwSt
Uniquely connecting theory with experimental data, this book highlights the potential of advanced computational methods in cancer research. Beginning with a biological background, the reader is introduced to the principles of mathematical modeling, before being guided through case studies that demonstrate how modeling can aid our understanding of tumour biology.
Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Vittorio Cristini is Professor of Health Information Sciences and Biomedical Engineering at the University of Texas, and of Systems Biology at the M. D. Anderson Cancer Center, Houston. He is also Honorary Professor of Mathematics at the University of Dundee, Scotland. Professor Cristini is a leading researcher in the fields of mathematical and computational biology, complex fluids, materials science and mathematical oncology. He has published several chapters in books and over 60 journal articles. John Lowengrub is a Professor of Mathematics, Materials Science, and Biomedical and Chemical Engineering at the University of California, Irvine. He has published over 80 journal articles along with several book chapters. Professor Lowengrub is a leading researcher in the fields of mathematical and computational biology, mathematical oncology, complex fluids, and materials science. His research has been supported by various institutions including the National Science Foundation, the National Institutes of Health, and the State of California.

Part I. Theory: 1. Introduction; 2. Biological background; 3. Continuum tumor modeling: single phase; 4. Analysis and calibration of single-phase continuum tumor models; 5. Continuum tumor modeling: multiphase; 6. Discrete cell modeling; 7. Hybrid continuum-discrete models; 8. Numerical schemes; Part II. Applications: 9. Continuum tumor modeling: a multidisciplinary approach; 10. Agent-based cell modeling: application to breast cancer.

Erscheint lt. Verlag 9.9.2010
Zusatzinfo 5 Tables, black and white; 55 Line drawings, black and white
Verlagsort Cambridge
Sprache englisch
Maße 180 x 254 mm
Gewicht 750 g
Themenwelt Mathematik / Informatik Mathematik Angewandte Mathematik
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Physiotherapie / Ergotherapie Orthopädie
Technik Medizintechnik
ISBN-10 0-521-88442-X / 052188442X
ISBN-13 978-0-521-88442-6 / 9780521884426
Zustand Neuware
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