Stem Cell Technologies: Basics and Applications

Satish M Totey is currently Chief Executive Officer and Co-Founder of Advance Neuroscience Allies Pvt. Ltd. A Ph.D from Jawaharlal Nehru University, New Delhi, Totey was a faculty at the National Institute of Immunology from 1983 to 2001. He moved to industry in 2001 and became the Director of Stem Cell Research at Reliance Life Sciences, Mumbai, India. In 2004 he move to Bangalore as Chief Scientific Officer, Stempeutics Research Pvt. Ltd. He established a research and production laboratory at Kuala Lumpur, Malaysia. He was also instrumental in industry scale manufacturing of mesenchymal stem cells from bone marrow, adipose tissues, dental pulp and umbilical cord. He is one of the pioneers in establishing human embryonic stem cell lines in the country and also established the first official clinical trials in India and Malaysia. Dr. Totey has published over 100 papers and edited 2 books and his research interests include neurodegenerative disorders. Kaushik D Deb is currently General Manager (Operations and Research) at ANSA Pvt. Ltd., leading research in the areas of epigenomics, directed stem cell trafficking and drug screening. A PhD from Jiwaji University, India, he completed post-doctoral training in the areas of stem cells and tissue engineering from universities in the US and Canada. He also has an executive MBA degree from the Indian Institute of Management, Bangalore.Dr. Deb was with Stempeutics Research Pvt. Ltd. as Group Leader for human embryonic stem cell program, and was involved in course design and establishment of the Manipal Institute of Regenerative Medicine, the first of its kind in India. He has published several peer-reviewed research papers and book chapters, and is also a reviewer and editor of several international journals. He is a founder member of the Stem Cell Research Forum of India (SCRFI) and the Society of Tissue Engineering and Regenerative Medicine India (STERMI).

List of Contributors; Foreword; Preface; Chapter 1. Stem Cells and Regenerative Medicine--The Evolving Story; Part 1: Embryonic Stem Cells; Chapter 2. Zebrafish Stem Cells; Chapter 3. Medaka Stem Cells; Chapter 4. Chicken Embryonic Stem Cells as Another Non-Mammalian Embryonic Stem Cell Type; Chapter 5. Derivation, Culture and Genetic Modification of Mouse Embryonic Stem Cells; Chapter 6. Derivation of Human Embryonic Stem Cells from Blastocysts; Chapter 7. Developing a Serum-free and a Novel Reporter System for hESCs; Chapter 8. Epigenetics and Embryonic Stem Cells; Chapter 9. Embryonic Stem Cells as Therapy for Diabetes; Chapter 10. Manipulation of Biomaterial Interface by Biomimetic Strategies: Possibilities of Exploring Stem Cells; Chapter 11. Immunomodulatory Aspects of Human Embryonic and Adult Stem Cells; Chapter 12. Human Embryonic Stem Cells as a Model System to Study Human Genetics; Chapter 13. Germ Cells and Artificial Gametes Production from Embryonic Stem Cells; Chapter 14. Using Embryonic Stem Cells to Introduce Mutations into the Mouse Germ Line: Animal Models and Future Applications; Chapter 15. Application of Human Embryonic Stem Cells in Drug Discovery; Part 2: Adult Stem Cells; Chapter 16. Recent Advancements on Tissue-Resident Adult Stem/Progenitor Cell Biology and Their Therapeutic Applications in Regenerative Medicine and Cancer Therapies;Chapter 17. Mesenchymal Stem Cells and their Therapeutic Potential in the Nervous System; Chapter 18. Mesenchymal Stem Cells: Culture Optimization and Potential Clinical Use; Chapter 19. Mesenchymal Stem Cells: Culture, Characterization and Therapeutic Applications in Neurodegenerative Diseases; Chapter 20. Dental Pulp Stem Cells and Perspectives of Future Application in Cell Therapy; Chapter 21. Hematopoletic Stem Cells and Their Dynamics; Chapter 22. Spermatogonial Stem Cells; Chapter 23. Epigenetics as a Cause for the Eloquent Silence of Stem Cells; Chapter 24. Cancer Stem Cells: The Enemy within Cancers; Chapter 25. Exploring the Potential of Adult Stem Cells: Why Umbilical Cord Blood?; Chapter 26. Cell Therapy and Tissue Engineering in Regenerative Medicine; Chapter 27. Biomaterials for Enhancing Corneas and Spinal Cord Regeneration; Index